CHROMATOGRAPHIC RESOLUTION OF RACEMIC AMINES, CARBOXYLIC-ACIDS, AND ALCOHOLS BY A NEW HOMOCHIRAL REAGENT DERIVED FROM ENDO-BORNEOL

被引：8

作者：

BANKS, MR

CADOGAN, JIG

DAWSON, IM

GOSNEY, I

GRANT, KJ

GAUR, S

HODGSON, PKG

STEVENSON, DE

机构：

[1] UNIV EDINBURGH,DEPT CHEM,W MAINS RD,EDINBURGH EH9 3JJ,MIDLOTHIAN,SCOTLAND

[2] BP RES CTR,SUNBURY TW16 7LN,MIDDX,ENGLAND

来源：

CHROMATOGRAPHIA | 1992年 / 34卷 / 1-2期

关键词：

COLUMN LIQUID CHROMATOGRAPHY; DIASTEREOMER SEPARATION; CHIRAL DERIVATIZING AGENT; CHIRAL OXAZOLIDIN-2-ONE;

D O I：

10.1007/BF02290458

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Chromatographic separation of racemic amines, carboxylic acids and alcohols can be achieved with excellent resolution as measured in terms of the chromatographic separation factor-alpha by derivatization with a homochiral oxazolidin-2-one easily prepared in three steps from endo-borneol. The resolved materials can be isolated in excellent yields by cleavage of the resultant diastereomers using conventional methods, which also allow recovery of the chiral resolving agent for re-use.

引用

页码：48 / 50

页数：3

共 8 条

[1]

[Anonymous], ASYMMETRIC SYNTHESIS

[2] SEPARATION OF AMINO-ACID ENANTIOMERS AND CHIRAL AMINES USING PRECOLUMN DERIVATIZATION WITH (+)-1-(9-FLUORENYL)ETHYL CHLOROFORMATE AND REVERSED-PHASE LIQUID-CHROMATOGRAPHY [J].