INVESTIGATION OF POSSIBLE TOXICOLOGICAL INFLUENCES OF SIMMONDSIN AFTER SUBACUTE ADMINISTRATION IN THE RAT

被引：17

作者：

COKELAERE, MM

DANGREAU, HD

DAENENS, P

BRUNEEL, N

ARNOUTS, S

DECUYPERE, EMP

KUHN, ER

机构：

[1] KATHOLIEKE UNIV LEUVEN,PHYSIOL & IMMUNOL DOMEST ANIM,B-3001 HEVERLEE,BELGIUM

[2] PROVINCIALE IND HSCH,B-8500 KORTRIJK,BELGIUM

[3] CATHOLIC UNIV LEUVEN,TOXICOL LAB,B-3000 LOUVAIN,BELGIUM

[4] CATHOLIC UNIV LEUVEN,COMPARAT ENDOCRINOL LAB,B-3000 LOUVAIN,BELGIUM

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 1992年 / 40卷 / 12期

关键词：

D O I：

10.1021/jf00024a020

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

A 5-day administration of 250 mg of simmondsin/kg of body weight did not have any toxicological influences on liver, pancreas, and kidneys using several biochemical parameters. Anatomopathological investigation of kidney, liver, pancreas, stomach, intestine, testis, and seminal vesicle also did not demonstrate any pathological change. Since the concentrations of CN- and of SCN- in the blood are not elevated, it is concluded that there are no indications for a liberation of HCN during the metabolism of simmondsin in the rat. The food intake inhibition and weight-reducing effect of gastrally intubated simmondsin in rats has been confirmed, but there are no indications that HCN causes the food intake reduction or the weight loss after simmondsin intake in rats.

引用

页码：2443 / 2445

页数：3

共 11 条

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