INHIBITION OF IRON-ABSORPTION PROLONGS THE LIFE-SPAN OF DROSOPHILA

被引：46

作者：

MASSIE, HR

AIELLO, VR

WILLIAMS, TR

机构：

[1] Masonic Medical Research Laboratory, Utica, NY 13501

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 1993年 / 67卷 / 03期

关键词：

IRON; DROSOPHILA; AGING; TEA; CALCIUM; LIFE SPAN;

D O I：

10.1016/0047-6374(93)90001-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The life span of Drosophila melanogaster (Oregon R) males was found to be proportional to the logarithm of the iron content of the diet. Life span was also shown to be proportional to the rate of iron accumulation for Drosophila, mice and man. The total body iron content was found to correlate with the total calcium content of adult Drosophila. Iron content during the developmental stages, however, remained relatively constant and did not change with changes in the calcium concentrations. Dietary tea (Camellia sinensis) extracts were found to inhibit the ageing-related accumulation of iron and to prolong the life span of Drosophila by as much as 21.4%. It is concluded that iron accumulation is a significant factor contributing to senescence.

引用

页码：227 / 237

页数：11

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