ROLE OF GASTRIC-MUCOSAL BLOOD-FLOW IN GASTROPROTECTIVE EFFECT OF NOVEL XANTHINE DERIVATIVE

被引：4

作者：

TANAKA, T

GUTH, PH

机构：

[1] UNIV CALIF LOS ANGELES,VET ADM MED CTR,CTR ULCER RES & EDUC,WILSHIRE BLVD,SAWTELLE BLVD,LOS ANGELES,CA 90073

[2] UNIV CALIF LOS ANGELES,VET ADM MED CTR,MED & RES SERV,LOS ANGELES,CA 90073

来源：

DIGESTIVE DISEASES AND SCIENCES | 1994年 / 39卷 / 03期

关键词：

XANTHINE DERIVATIVE; GASTRIC MUCOSAL BLOOD FLOW; GASTROPROTECTION; ENDOGENOUS PROSTAGLANDIN;

D O I：

10.1007/BF02088347

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The effect of 3-ethyl-1-(6-hydroxy-6-methylheptyl)-7-propylxanthine (A90 6119) on 40% ethanol-induced gastric lesions and gastric mucosal blood flow was investigated in rats. Gastric mucosal blood flow was measured by the hydrogen gas clearance technique and the test compounds and vehicle were administered intraduodenally. A90 6119 dose-dependently increased gastric mucosal blood flow and decreased gross and histologic gastric mucosal injury induced by 40% ethanol. Both the gastric mucosal blood flow and protective effects of A90 6119 were completely attenuated by pretreatment with indomethacin. The findings demonstrate that A90 6119 protects against ethanol-induced gastric injury, and this effect involves stimulation of endogenous prostaglandin synthesis and an increase in gastric mucosal blood flow.

引用

页码：587 / 592

页数：6

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