BROWNIAN DYNAMICS SIMULATION OF DNA GEL-ELECTROPHORESIS

被引：16

作者：

MATSUMOTO, M

DOI, M

机构：

[1] Department of Applied Physics, School of Engineering, Nagoya University

来源：

MOLECULAR SIMULATION | 1994年 / 12卷 / 3-6期

关键词：

BROWNIAN DYNAMICS; DNA; GEL ELECTROPHORESIS; POLYMER DYNAMICS;

D O I：

10.1080/08927029408023032

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Brownian dynamics computer simulation technique was applied to investigate DNA dynamics in gel electrophoresis. Under a constant electric field of moderate strength, large DNA chains take stretched and contracted conformations alternatively during the migration. The conformation change is quasi-periodic under certain conditions, and its frequency is closely related to the experimentally-found suitable frequency of pulse field gel electrophoresis.

引用

页码：219 / 226

页数：8

共 17 条

[1]

Birren B, 1993, PULSED FIELD GEL ELE, DOI 10.1016/B978-0-12-101290-8.50002-X

[2] DIRECT OBSERVATION AND MANIPULATION OF SINGLE DNA-MOLECULES USING FLUORESCENCE MICROSCOPY [J].