BETA-LACTAM RESISTANCE AMONG ESCHERICHIA-COLI AND KLEBSIELLA SPECIES BLOOD CULTURE ISOLATES IN FINNISH HOSPITALS

被引：9

作者：

ARSTILA, T ^{[1
]}

AUVINEN, H ^{[1
]}

HUOVINEN, P ^{[1
]}

AHONEN, E ^{[1
]}

BRANDER, M ^{[1
]}

EEROLA, E ^{[1
]}

ESKOLA, J ^{[1
]}

HAKKARAINEN, K ^{[1
]}

HERVA, E ^{[1
]}

HIRVAS, L ^{[1
]}

HIRVONEN, P ^{[1
]}

JAGERROOS, H ^{[1
]}

JARVINEN, H ^{[1
]}

KATILA, ML ^{[1
]}

KLOSSNER, ML ^{[1
]}

KONTIAINEN, S ^{[1
]}

KORPELA, J ^{[1
]}

KOSKELA, M ^{[1
]}

KOSTIALATHOMPSON, A ^{[1
]}

KARKKAINEN, P ^{[1
]}

LARINKARI, U ^{[1
]}

LEHTONEN, OP ^{[1
]}

LIIMATAINEN, O ^{[1
]}

NISSINEN, A ^{[1
]}

OINONEN, S ^{[1
]}

RENKONEN, OV ^{[1
]}

RUUSKA, P ^{[1
]}

SARKKINEN, H ^{[1
]}

VIKBERG, V ^{[1
]}

机构：

[1] KANTA HAME CENT HOSP,SF-13530 HAMEENLINNA,FINLAND

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 1994年 / 13卷 / 06期

关键词：

D O I：

10.1007/BF01974636

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The aim of this study was to investigate beta-lactam resistance in Escherichia coli and Klebsiella spp. blood culture isolates in Finland. Special attention was given to extended-spectrum beta-lactamases. A total of 566 Escherichia coli and 108 Klebsiella spp. blood culture isolates were collected from hospitals throughout Finland and their susceptibility to beta-lactam antibiotics studied. Twenty percent of Escherichia coli and 69% of Klebsiella spp. strains were resistant to ampicillin. The mechanisms of resistance were studied by hybridization, isoelectric focusing and the clavulanate double-disk potentiation test. Of the ampicillin-resistant Escherichia coli strains, 83% produced TEM-1. Of the ampicillin-resistant Klebsiella spp. strains, 43% produced SHV-1. Only nine Escherichia coli and three Klebsiella spp. isolates were resistant to cefuroxime (MIC > 32 mu g/ml), and none were resistant to third-generation cephalosporins. These data were compared with cefuroxime and third-generation cephalosporin consumption levels in Finnish hospitals. Although the use of cephalosporins is far more extensive in Finland than in other Scandinavian countries, none of the isolates produced extended-spectrum beta-lactamases. In conclusion, resistance to cefuroxime has remained rare in Finland, and cefuroxime is still an alternative to third-generation cephalosporins in the treatment of septicemia.

引用

页码：468 / 474

页数：7

共 22 条

[1] ANALYSIS OF BETA-LACTAMASE PRODUCTION IN AMPICILLIN-RESISTANT ESCHERICHIA-COLI ISOLATED FROM BLOOD CULTURES 1983-1989 [J].