MAPPING OF THE HUMAN GENE FOR INDUCIBLE HEME OXYGENASE TO CHROMOSOME-22Q12

被引：20

作者：

KUWANO, A

IKEDA, H

TAKEDA, K

NAKAI, H

KONDO, I

SHIBAHARA, S

机构：

[1] TOHOKU UNIV, SCH MED, DEPT APPL PHYSIOL & MOLEC BIOL, 2-1 SEIRYO MACHI, SENDAI, MIYAGI 980, JAPAN

[2] EHIME UNIV, SCH MED, DEPT HYG, SHIGENOBU, EHIME 79102, JAPAN

来源：

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE | 1994年 / 172卷 / 04期

关键词：

HEME OXYGENASE; CHROMOSOME MAPPING; SOMATIC CELL HYBRIDS; FLUORESCENCE IN-SITU HYBRIDIZATION;

D O I：

10.1620/tjem.172.389

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heme oxygenase is an essential enzyme in heme catabolism that cleaves heme to form biliverdin, releasing carbon monoxide and iron. There are two isozymes of heme oxygenase: heme oxygenase 1 (HO-1) and heme oxygenase 2, each of which is encoded by a separate gene. It is noteworthy that HO-1 is inducible by various environmental factors, while heme oxygenase 2 is not. Here we have localized the human HO-1 gene to chromosome 22 by polymerase chain reaction (PCR) analysis of human-hamster somatic cell hybrids. The precise region of the HO-1 locus was then determined by fluorescence in situ hybridization, revealing that the human HO-1 gene is localized to 22q12.

引用

页码：389 / 392

页数：4

共 12 条

[1] HUMAN CHROMOSOME-22 [J].