ASTHMA SYMPTOMS AND AIRWAY HYPERRESPONSIVENESS ARE LOWER DURING TREATMENT WITH NEDOCROMIL SODIUM THAN DURING TREATMENT WITH REGULAR INHALED ALBUTEROL

被引:16
作者
WASSERMAN, SI
FURUKAWA, CT
HENOCHOWICZ, SI
MARCOUX, JP
PRENNER, BM
FINDLAY, SR
GROSS, GN
HUDSON, LD
MYERS, DJ
STEINBERG, P
机构
[1] MAYO CLIN & MAYO FDN,DEPT INTERNAL MED ALLERG DIS,ROCHESTER,MN 55905
[2] HARBORVIEW MED CTR,SEATTLE,WA
[3] HENNEPIN CTY MED CTR,MINNEAPOLIS,MN
关键词
NEDOCROMIL SODIUM; ANTIINFLAMMATORY; ALBUTEROL; ASTHMA;
D O I
10.1016/S0091-6749(95)70316-0
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
In a double-blind, double-dummy, multicenter study, 212 patients with asthma whose symptoms were not controlled by as-needed use of inhaled bronchodilators were randomized to receive either 4 mg of nedocromil sodium or 180 mu g of albuterol four times daily for 12 weeks. Asthma symptom scores (daytime asthma, nighttime asthma, morning chest tightness, and cough) and peak expiratory flow rate were recorded daily on diary cards. Bronchial hyperresponsiveness was assessed by changes in diurnal variation in peak expiratory flow rate and by methacholine inhalation challenge. Statistically significant differences were found between groups favoring nedocromil sodium for relief of day and nighttime asthma and morning chest tightness. Patients treated with nedocromil sodium also had significantly lower diurnal variation in peak expiratory flow rate compared with patients treated with albuterol. Compared with patients treated with albuterol, patients treated with nedocromil sodium showed a greater improvement in cough and a decreased sensitivity to methacholine challenge. Patients in both groups reduced their as-needed albuterol use. Regular treatment with nedocromil sodium therefore led to greater asthma symptom control and reduced bronchial responsiveness compared with regular treatment with albuterol. The study also showed that more frequent we of a beta(2)-agonist (for symptom relief or not) did nor improve asthma central. Both drugs were well tolerated.
引用
收藏
页码:541 / 547
页数:7
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