EXCITATORY AMINO-ACID RECEPTORS IN CENTRAL CARDIOVASCULAR REGULATION

被引：25

作者：

GORDON, FJ

机构：

[1] Department of Pharmacology, Emory University School of Medicine, Atlanta

来源：

CLINICAL AND EXPERIMENTAL HYPERTENSION | 1995年 / 17卷 / 1-2期

关键词：

CENTRAL NERVOUS SYSTEM; EXCITATORY AMINO ACIDS; BARORECEPTOR REFLEXES; BLOOD PRESSURE;

D O I：

10.3109/10641969509087056

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Excitatory amino acid neurotransmitters and their receptors are the principal mediators of fast synaptic transmission within the central nervous system. Accumulating evidence suggests that synaptic activation of excitatory amino acid receptors in the nucleus of the tractus solitarius, rostral and caudal ventrolateral medulla, and in the spinal cord play a key role in neural transmission of cardiovascular information in the central nervous system. Pharmacological blockade of excitatory amino acid receptors at these sites eliminates a variety of centrally-mediated cardiovascular responses. These include baroreceptor reflexes and increases in arterial pressure produced by stimulation of various brain regions as well as peripheral afferent nerves. These observations indicate that synaptic activation of EAA receptors at specific sites within the brainstem and in the spinal cord play an important role in central cardiovascular regulation.

引用

页码：81 / 90

页数：10

共 35 条

[1]

Collingridge G.L., Lester R.A.J., Excitatory amino acid receptors in the vertebrate central nervous system, Pharmacol. Rev., 40, pp. 143-210, (1989)

[2]

Gordon F.J., Talman W.T., Role of excitatory amino acids and their receptors in bulbospinal control of cardiovascular function, Central Neural Mechanisms in Cardiovascular Regulation, 2, pp. 209-225, (1992)

[3]

Talman W.T., Granata A.R., Reis D.J., Glutamatergic mechanisms in the nucleus tractus solitarius in blood pressure control, Fed. Proc., 43, pp. 39-44, (1984)

[4]

Leone C., Gordon F.J., Is L-glutamate a neurotransmitter of baroreceptor information in the nucleus of the tractus solitarius? J, Pharmacol. Exp. Ther., 250, pp. 953-962, (1989)

[5]

Talman W.T., Kynurenic acid microinjected into the nucleus tractus solitarius of rat blocks the arterial baroreflex but not responses to glutamate, Neurosci. Lett., 102, pp. 247-252, (1989)

[6]

Conn P.J., Desai M.A., Pharmacology and physiology of metabotropic glutamate receptors in the mammalian central nervous system, Drug Dev. Res., 24, pp. 207-229, (1991)

[7]

Pawloski-Dahm C., Gordon F.J., Evidence for a kynurenate-insensitive glutamate receptor in the nucleus tractus solitarius, Am. J. Physiol., (1992)

[8]

Kubo T., Kihara M., Evidence of N-methyl-D-aspartate receptor-mediated modulation of the aortic baroreceptor reflex in the rat nucleus tractus solitarii, Neurosci. Lett., 87, pp. 69-74, (1988)

[9]

Florentino A., Varga K., Kunos G., Mechanism of the cardiovascular effects of GABA<sub>B</sub> receptor activation in the nucleus tractus solitarii of the rat, Brain Res., 535, pp. 264-270, (1990)

[10]

Le Galloudec E., Merahi N., Laguzzi R., Cardiovascular changes induced by the local application of glutamate-related drugs in the rat nucleus tractus solitarii, Brain Res., 503, pp. 322-325, (1989)

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