PRESENCE OF DITYROSINE BRIDGES IN THYROGLOBULIN AND THEIR RELATIONSHIP WITH IODINATION

被引：13

作者：

LEONARDI, A

ACQUAVIVA, R

MARINACCIO, M

LIGUORO, D

FOGOLARI, F

DIJESO, B

FORMISANO, S

CONSIGLIO, E

机构：

[1] FAC MED & CHIRURG UDINE 2,DIPARTIMENTO SCI & TECNOL BIOMED,UDINE,ITALY

[2] CNR,FAC MED & CHIRURG 2,DIPARTIMENTO BIOL & PATOL CELLULARE & MOLEC L CAL,I-80125 NAPLES,ITALY

[3] CNR,FAC MED & CHIRURG 2,CTR ENDOCRINOL & ONCOL SPERIMENTALE,I-80125 NAPLES,ITALY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 202卷 / 01期

关键词：

D O I：

10.1006/bbrc.1994.1890

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The presence of dimeric thyroglobulin (19S), after reduction and alkylation, suggests that within thyroglobulin there may be intermolecular cross-links, other than disulphide bridges. However, the nature of these intermolecular cross-links is still unknown. In this study, we show the presence of 3-3' dityrosine bridges in the molecule of bovine thyroglobulin by NMR and fluorescence studies. Also, we evaluated the role of iodination in dityrosine formation in vivo and in vitro. (C) 1994 Academic Press, Inc.

引用

页码：38 / 43

页数：6

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