A COMPARATIVE-STUDY OF THE FORMATION OF CHEMICALLY REACTIVE DRUG METABOLITES BY HUMAN-LIVER MICROSOMES

被引:37
作者
KITTERINGHAM, NR [1 ]
LAMBERT, C [1 ]
MAGGS, JL [1 ]
COLBERT, J [1 ]
PARK, BK [1 ]
机构
[1] UNIV LIVERPOOL,DEPT PHARMACOL & THERAPEUT,POB 147,LIVERPOOL L69 3BX,ENGLAND
基金
英国惠康基金;
关键词
D O I
10.1111/j.1365-2125.1988.tb03358.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:13 / 21
页数:9
相关论文
共 33 条
[1]   ORAL CONTRACEPTION, CIRCULATING IMMUNE-COMPLEXES, ANTI-ETHINYLESTRADIOL ANTIBODIES, AND THROMBOSIS [J].
BEAUMONT, V ;
LEMORT, N ;
BEAUMONT, JL .
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 1982, 2 (01) :8-12
[2]   MONO-OXYGENASE ACTIVITY OF HUMAN-LIVER IN MICROSOMAL FRACTIONS OF NEEDLE-BIOPSY SPECIMENS [J].
BOOBIS, AR ;
BRODIE, MJ ;
KAHN, GC ;
FLETCHER, DR ;
SAUNDERS, JH ;
DAVIES, DS .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1980, 9 (01) :11-19
[3]   EVIDENCE FOR CLARA CELL AS A SITE OF CYTOCHROME P450-DEPENDENT MIXED-FUNCTION OXIDASE ACTIVITY IN LUNG [J].
BOYD, MR .
NATURE, 1977, 269 (5630) :713-715
[4]  
CLAESEN M, 1982, DRUG METAB DISPOS, V10, P667
[5]   SYNTHESIS, DECOMPOSITION KINETICS, AND PRELIMINARY TOXICOLOGICAL STUDIES OF PURE N-ACETYL-P-BENZOQUINONE IMINE, A PROPOSED TOXIC METABOLITE OF ACETAMINOPHEN [J].
DAHLIN, DC ;
NELSON, SD .
JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (08) :885-886
[6]  
DEJONGH GD, 1981, DRUG METAB DISPOS, V94, P58
[7]   CARCINOGENS, DRUGS, AND CYTOCHROMES-P-450 [J].
GELBOIN, HV .
NEW ENGLAND JOURNAL OF MEDICINE, 1983, 309 (02) :105-107
[8]   METABOLIC-ACTIVATION OF THE TRICYCLIC ANTIDEPRESSANT AMINEPTINE BY HUMAN-LIVER CYTOCHROME-P-450 [J].
GENEVE, J ;
LARREY, D ;
AMOUYAL, G ;
BELGHITI, J ;
PESSAYRE, D .
BIOCHEMICAL PHARMACOLOGY, 1987, 36 (14) :2421-2424
[9]   METABOLIC-ACTIVATION OF THE TRICYCLIC ANTIDEPRESSANT AMINEPTINE .2. PROTECTIVE ROLE OF GLUTATHIONE AGAINST INVITRO AND INVIVO COVALENT BINDING [J].
GENEVE, J ;
DEGOTT, C ;
LETTERON, P ;
TINEL, M ;
DESCATOIRE, V ;
LARREY, D ;
AMOUYAL, G ;
PESSAYRE, D .
BIOCHEMICAL PHARMACOLOGY, 1987, 36 (03) :331-337
[10]  
GREENLEE WF, 1978, J PHARMACOL EXP THER, V205, P596