2,3-DIHYDROXY-6-NITRO-7-SULFAMOYL-BENZO(F)QUINOXALINE - A NEUROPROTECTANT FOR CEREBRAL-ISCHEMIA

被引：1155

作者：

SHEARDOWN, MJ

NIELSEN, EO

HANSEN, AJ

JACOBSEN, P

HONORE, T

机构：

[1] A/S Ferrosan, CNS Division, DK-2860 Soeborg

来源：

SCIENCE | 1990年 / 247卷 / 4942期

关键词：

D O I：

10.1126/science.2154034

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) is an analog of the quinoxalinedione antagonists to the non-N-methyl-D-aspartate (non-NMDA) glutamate receptor. NBQX is a potent and selective inhibitor of binding to the quisqualate subtype of the glutamate receptor, with no activity at the NMDA and glycine sites. NBQX protects against global ischemia, even when administered 2 hours after an ischemic challenge.

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页码：571 / 574

页数：4

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