ORGANIZATION AND SEQUENCES AT THE 5' END OF A CLONED COMPLETE OVALBUMIN GENE

被引：308

作者：

GANNON, F

OHARE, K

PERRIN, F

LEPENNEC, JP

BENOIST, C

COCHET, M

BREATHNACH, R

ROYAL, A

GARAPIN, A

CAMI, B

CHAMBON, P

机构：

[1] FAC MED STRASBOURG, INST CHIM BIOL,INSERM,UNITE 184,CNRS, GENET MOLEC EUCARYOTES LAB, F-67085 STRASBOURG, FRANCE

[2] INST PASTEUR, CNRS, EQUIPE RECH 201, GROUPE BIOL MOLEC GENE, F-75015 PARIS, FRANCE

来源：

NATURE | 1979年 / 278卷 / 5703期

关键词：

D O I：

10.1038/278428a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A clone which contains the complete chicken ovalbumin gene, including its leader coding sequences, has been isolated. From electron microscopic analysis of this DNA we conclude that the minimal size of the transcriptional unit for ovalbumin is 7.7 kilobases. The DNA sequence of the region surrounding the 5' end of the ovalbumin gene is presented. Comparison of this sequence with those of other eukaryotic genes reveals striking similarities, possibly related to a promoter region, approximately 30 base pairs upstream from the site coding for the 5′ end of the mRNA. © 1979 Nature Publishing Group.

引用

页码：428 / 434

页数：7

共 45 条

[1]

AKUSJARVI G, CELL

[2] SEQUENCE-ANALYSIS OF OPERATOR CONSTITUTIVE MUTANTS OF TRYPTOPHAN OPERON OF ESCHERICHIA-COLI [J].

BENNETT, GN ;

YANOFSKY, C .

JOURNAL OF MOLECULAR BIOLOGY, 1978, 121 (02) :179-192

[3] OVALBUMIN GENE IS SPLIT IN CHICKEN DNA [J].

BREATHNACH, R ;

MANDEL, JL ;

CHAMBON, P .

NATURE, 1977, 270 (5635) :314-319

[4] OVALBUMIN GENE - EVIDENCE FOR A LEADER SEQUENCE IN MESSENGER-RNA AND DNA SEQUENCES AT EXON-INTRON BOUNDARIES [J].

BREATHNACH, R ;

BENOIST, C ;

OHARE, K ;

GANNON, F ;

CHAMBON, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (10) :4853-4857

[5]

BREATHNACH R, 1978, P INT S GENET ENGNG, P77

[6]

CALOS MP, 1978, NATURE, V274, P762, DOI 10.1038/274762a0

[7] RATES OF FORMATION AND THERMAL STABILITIES OF RNA-DNA AND DNA-DNA DUPLEXES AT HIGH-CONCENTRATIONS OF FORMAMIDE [J].

CASEY, J ;

DAVIDSON, N .

NUCLEIC ACIDS RESEARCH, 1977, 4 (05) :1539-1552

[8]

CATTERALL JF, 1978, NATURE, V275, P510, DOI 10.1038/275510a0

[9]

Chamberlin M., 1976, RNA POLYMERASE, V6, P193

[10]

CHAMBON P, 11TH P MIAM WINT S

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