PHOTODYNAMIC THERAPY OF ESOPHAGEAL-CARCINOMA

被引：49

作者：

OKUNAKA, T

KATO, H

CONAKA, C

YAMAMOTO, H

BONAMINIO, A

ECKHAUSER, ML

机构：

[1] Department of Surgery, Tokyo Medical College, Tokyo, 160

[2] Department of Surgery, Metrohealth Medical Center, Case Western Reserve University, Cleveland, Ohio, 44109

来源：

SURGICAL ENDOSCOPY-ULTRASOUND AND INTERVENTIONAL TECHNIQUES | 1990年 / 4卷 / 03期

关键词：

Argon dye laser; Endoscope; Esophageal cancer; Hematoporphyrin derivative; Photodynamic therapy;

D O I：

10.1007/BF02336594

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Photodynamic therapy (PDT) utilizing either hematoporphyrin derivative or Photofrin II is proving to be an effective modality in the treatment of early superficial (ES) or advanced invasive (AI) carcinoma of the esophagus. An argon-pumped dye laser was used to deliver 630 nm light via quartz fibers passed through the biopsy channel of a gastroscope after intravenous injection of photosensitizer. Between 1982 and 1989, 20 patients (ES=6; AI=14) were treated in this manner. Complete remission was obtained in 4 of 6 ES cases, and the mean survival after PDT alone or in combination with other therapy was 27 months. Five patients remain alive to date. In the AI group, significant remissions were obtained in 6 cases while partial remissions were observed in another 8. The mean dysphagia grade improved from 4.0 to 2.8. We conclude that PDT is efficacious in the treatment of ES esophageal cancer, where complete remission may be achieved, and as palliative therapy in advanced cases to alleviate dysphagia. © 1990, Springer-Verlag. All rights reserved.

引用

页码：150 / 153

页数：4

共 15 条

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