INCREASED GENE-EXPRESSION OF MATRIX METALLOPROTEINASE-3 (STROMELYSIN) IN SKIN FIBROBLASTS FROM PATIENTS WITH SEVERE RECESSIVE DYSTROPHIC EPIDERMOLYSIS-BULLOSA

被引：25

作者：

SAWAMURA, D

SUGAWARA, T

HASHIMOTO, I

BRUCKNERTUDERMAN, L

FUJIMOTO, D

OKADA, Y

UTSUMI, N

SHIKATA, H

机构：

[1] MEIKAI UNIV,SCH DENT,DEPT ORAL PATHOL,SAKADO,SAITAMA 35002,JAPAN

[2] HIROSAKI UNIV,DEPT DERMATOL,HIROSAKI,AOMORI 036,JAPAN

[3] TOKYO NOKO UNIV,DEPT BIOCHEM,TOKYO,JAPAN

[4] KANAZAWA UNIV,DEPT PATHOL,KANAZAWA,ISHIKAWA 920,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 174卷 / 02期

关键词：

D O I：

10.1016/0006-291X(91)91518-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gene expression of matrix metalloproteinase 3 (MMP-3=stromelysin) was examined in the skin fibroblasts obtained from patients with severe recessive dystrophic epidermolysis bullosa (RDEB). Steady-state mRNA level of MMP-3 was selectively increased in the unstimulated RDEB cells by a post-transcriptional mechanism. A parallel study on the susceptibility of type VII collagen to MMPs revealed that this type of collagen is degraded by MMP-3, but not by MMP-1(collagenase). These data suggest that MMP-3 may play an important role in the blister formation of the skin in RDEB patients by the degradation of anchoring fibrils consisting of type VII collagen. © 1991.

引用

页码：1003 / 1008

页数：6

共 16 条

[1] EPIDERMOLYSIS BULLOSA DYSTROPHICA RECESSIVE - POSSIBLE ROLE OF ANCHORING FIBRILS IN PATHOGENESIS [J].