INTERACTION BETWEEN RADIATION AND DRUG DAMAGE IN MAMMALIAN-CELLS .3. EFFECT OF ADRIAMYCIN AND ACTINOMYCIN-D ON THE REPAIR OF POTENTIALLY LETHAL RADIATION-DAMAGE

被引：23

作者：

DRITSCHILO, A ^{[1
]}

PIRO, AJ ^{[1
]}

BELLI, JA ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,JOINT CTR RADIAT THERAPY,DEPT RADIAT THERAPY,BOSTON,MA 02115

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 1979年 / 35卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1080/09553007914550661

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have studied the effects of actinomycin-D (AMD) and Adriamycin (ADRM) on the repair of radiation damage in Chinese hamster cells (V79) in plateau phase growth. Suppression of potentially lethal damage repair (PLDR) was observed in the presence of non-toxic levels of AMD and minimally toxic levels of ADRM. The suppression of PLDR by AMD persisted as long as the drug was present Removal of AMD was followed by prompt repair of potentially lethal injury suggesting that suppression of PLDR by AMD was not accompanied by fixation of injury to a non-repairable state. On the other hand, irradiated cells exposed to ADRM eventually repair potentially lethal injury in the presence of drug after an initial delay. AMD, but not ADRM, inhibited repair of sublethal radiation damage. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：549 / 560

页数：12

共 20 条

[1]

BELLI JA, 1977, CANCER RES, V37, P1624

[2] POTENTIALLY LETHAL RADIATION DAMAGE - REPAIR BY MAMMALIAN CELLS IN CULTURE [J].

BELLI, JA ;

SHELTON, M .

SCIENCE, 1969, 165 (3892) :490-&

[3]

BELLI JA, 1970, FRONTIERS RADIATION, V5, P40

[4]

DOUPLE EB, 1975, RADIAT RES, V62, P552

[5] REPAIR OF RADIATION-DAMAGE IN PLATEAU-PHASE MAMMALIAN-CELLS - RELATIONSHIP BETWEEN SUBLETHAL AND POTENTIALLY LETHAL DAMAGE STATES [J].

DRITSCHILO, A ;

PIRO, AJ ;

BELLI, JA .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1976, 30 (06) :565-569

[6] ACTINOMYCIN D - SUPPRESSION OF RECOVERY IN X-IRRADIATED MAMMALIAN CELLS [J].

ELKIND, MM ;

ALESCIO, T ;

WHITMORE, GF .

SCIENCE, 1964, 143 (361) :1454-&

[7] MODIFICATION OF RECOVERY FROM POTENTIALLY LETHAL X-RAY DAMAGE IN PLATEAU PHASE CHINESE-HAMSTER CELLS [J].

EVANS, RG ;

BAGSHAW, MA ;

GORDON, LF ;

KURKJIAN, SD ;

HAHN, GM .

RADIATION RESEARCH, 1974, 59 (03) :597-605

[8]

HAHN G M, 1972, Current Topics in Radiation Research Quarterly, V8, P39

[9]

HAHN GM, 1974, CANCER RES, V34, P351

[10] REPAIR OF POTENTIALLY LETHAL LESIONS IN X-IRRADIATED, DENSITY-INHIBITED CHINESE-HAMSTER CELLS - METABOLIC EFFECTS AND HYPOXIA [J].

HAHN, GM ;

BAGSHAW, MA ;

EVANS, RG ;

GORDON, LF .

RADIATION RESEARCH, 1973, 55 (02) :280-290

← 1 2 →