PLASMA-CONCENTRATIONS OF ENDOTHELIN IN MAN - ARTERIOVENOUS DIFFERENCES AND RELEASE DURING VENOUS STASIS

被引：53

作者：

WAGNER, OF

NOWOTNY, P

VIERHAPPER, H

WALDHAUSL, W

机构：

[1] I Medizinische Universitatsklinik, Division of Clinical Endocrinology and Diabetes Mellitus, Vienna

来源：

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 1990年 / 20卷 / 05期

关键词：

Arterio‐venous difference; endothelin; human plasma; venous stasis;

D O I：

10.1111/j.1365-2362.1990.tb01892.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Abstract. Endothelin‐1 is a recently described endothe‐lium‐derived vasoconstricting peptide. Plasma concentrations of immunoreactive (IR‐) endothelin were investigated in six healthy young men applying a radioimmunoassay after extraction of endothelin from plasma. In venous plasma a mean concentration of 1.3 pM; 0.4 pmol 1‐1 was found, whereas the mean concentration in arterial plasma was 0.9 pM; 0.4 pmol 1‐1 (p< 0.005). During venous stasis for 10 min the mean plasma concentration of IR‐endothelin increased about twofold, from basal 1.1pM;0.3 pmol l‐1 to 2.1pM;0.3 pmol 1‐1 (p<0.01). This manoeuvre may prove helpful to investigate the control of endothelin in vivo under a variety of pathological conditions. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：502 / 505

页数：4

共 9 条

[1] PRESENCE OF IMMUNOREACTIVE ENDOTHELIN IN HUMAN-PLASMA [J].