EVIDENCE OF IGG-MEDIATED ENHANCEMENT OF THE ANTIBODY-RESPONSE INVIVO WITHOUT COMPLEMENT ACTIVATION VIA THE CLASSICAL PATHWAY

被引:35
作者
WIERSMA, EJ
NOSE, M
HEYMAN, B
机构
[1] BIOMED CTR,DEPT IMMUNOL,S-75123 UPPSALA,SWEDEN
[2] TOHOKU UNIV,SCH MED,SENDAI,MIYAGI 980,JAPAN
关键词
D O I
10.1002/eji.1830201209
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The complement (C) dependency of IgG-mediated enhancement of the antibody response was investigated by immunizing mice with trinitrophenyl-coupled keyhole limpet hemocyanin (TNP-KLH) and either a C-activating TNP-specific monoclonal IgG2a antibody (Hy-1.2) or a mutant, non-C-activating variant of Hy-1.2 (M12). Hy-1.2 as well as M12 efficiently enhanced the anti-KLH response, although Hy-1.2 was more active. In addition, also a naturally non-C-activating TNP-specific IgG1 antibody enhanced the response to TNP-coupled bovine serum albumin. Moreover, C-activating IgG could enhance the antibody response in mice depleted of C3 by treatment with cobra venom factor. These findings suggest that the classical pathway of C activation is not required for IgG-mediated enhancement.
引用
收藏
页码:2585 / 2589
页数:5
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