DESIGN AND SYNTHESIS OF NEOCARZINOSTATIN ANALOGS

被引：9

作者：

HIRAMA, M

机构：

来源：

JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN | 1991年 / 49卷 / 11期

关键词：

NEOCARZINOSTATIN CHROMOPHORE ANALOG; SYNTHESIS; DNA CLEAVAGE; BASE SPECIFIC CLEAVAGE; DESIGN OF DNA CLEAVING MOLECULE; BINDING STRUCTURE; NEOCARZINOSTATIN COMPLEX; ANTITUMOR ACTIVITY; MASAMUNE-BERGMAN CYCLOAROMATIZATION; TRIGGERING MECHANISM;

D O I：

10.5059/yukigoseikyokaishi.49.1032

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first generation of 10 membered ring analogues (11 approximately 13) of the neocarzinostatin chromophore (1) could undergo the thiol or radical triggered Masamune-Bergman type cycloaromatization, but they were not able to show the antibiotic nor antitumor activities. New analogues (27 approximately 29) of the second generation exhibited the remarkable DNA cleaving activities as well as the biological activities. The unprecedented guanine specific DNA cleavage by the simple chiral alcohol 28 is striking, while the complex of the possible intercalator 29 with the neocarzinostatin apoprotein (2) did not show an evident specificity.

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页码：1032 / 1042

页数：11

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