UPTAKE OF [H-3] 2-DEOXY GLUCOSE BY LIGHT-ADAPTED AND DARK-ADAPTED RAT RETINAS INVIVO

被引：17

作者：

MORJARIA, B

VOADEN, MJ

机构：

[1] Department of Visual Science, Institute of Ophthalmology, London, WC1H 9QS, Judd Street

来源：

JOURNAL OF NEUROCHEMISTRY | 1979年 / 32卷 / 06期

关键词：

D O I：

10.1111/j.1471-4159.1979.tb02307.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As a preliminary to analysing substrate utilization by the rodent retina in various functional states, the in vivo uptake of 2-deoxy-D-glucose in light- and dark-adapted rat retinas was studied. This glucose analog can be phosphorylated, but not further metabolized, and the rate of its intracellular accumulation can be used as an index of glucose utilisation in the tissue. The results localize the decreased uptake of 2-deoxy glucose to photoreceptors and imply a decreased utilization of glucose when these cells are exposed to steady illumination.

引用

页码：1881 / +