EFFECTS OF INDOMETHACIN ON CEREBRAL HEMODYNAMICS AT REST AND DURING ENDOTRACHEAL SUCTIONING IN PRETERM NEONATES

被引：20

作者：

SALIBA, E ^{[1
]}

CHANTEPIE, A ^{[1
]}

AUTRET, E ^{[1
]}

GOLD, F ^{[1
]}

POURCELOT, L ^{[1
]}

LAUGIER, J ^{[1
]}

机构：

[1] UNIV TOURS,INSERM,UNITE 316,F-37041 TOURS,FRANCE

来源：

ACTA PAEDIATRICA SCANDINAVICA | 1991年 / 80卷 / 6-7期

关键词：

INDOMETHACIN; CEREBRAL HEMODYNAMICS; PRETERM NEONATES;

D O I：

10.1111/j.1651-2227.1991.tb11918.x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The effect of therapeutic doses of indomethacin versus placebo (saline) on cerebral hemodynamics was studied in nine mechanically ventilated preterm infants. Recordings were made at rest and during endotracheal suctioning. Indomethacin at a dose of 0.2 mg/kg body weight was infused over 5 min. Compared to placebo, there was a significant decrease in Doppler mean frequency in the anterior cerebral artery within minutes of starting the indomethacin infusion during the resting period after the first (p < 0.01), second (p < 0.001) and third (p < 0.025) doses. This effect has persisted during endoracheal suctioning. Thus, indomethacin alters cerebral hemodynamics by decreasing Doppler mean frequency. In view of these findings, and particularly because of the alteration in the resting cerebral hemodynamics, the recommendation of prophylactic treatment with indomethacin remains questionable.

引用

页码：611 / 615

页数：5

共 17 条

[1]

BANDSTRA ES, 1988, PEDIATRICS, V82, P533

[2] PHARMACOKINETICS OF INDOMETHACIN IN THE NEONATE - RELATION OF PLASMA INDOMETHACIN LEVELS TO RESPONSE OF THE DUCTUS-ARTERIOSUS [J].