NEONATAL TREATMENT WITH CLOMIPRAMINE INCREASED IMMOBILITY IN THE FORCED SWIM TEST - AN ATTRIBUTE OF ANIMAL-MODELS OF DEPRESSION

被引：54

作者：

VELAZQUEZ-MOCTEZUMA, J

DIAZ-RUIZ, O

机构：

[1] Departamento Biologia de la Reproduccion, Universidad Autonoma Metropolitana-Iztapalapa, Mexico City

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1992年 / 42卷 / 04期

关键词：

FORCED SWIMMING TEST; ANIMAL MODELS; DEPRESSION; CLOMIPRAMINE;

D O I：

10.1016/0091-3057(92)90022-8

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The forced swimming test in rats has been identified as a suitable model for detecting antidepressant activity of several drugs regardless of their mode of action. On the other hand, a number of animal models of human endogenous depression have been proposed. Recently, it has been reported that perinatal administration of clomipramine in rats elicits behavioral changes in adulthood that resemble human endogenous depression. In the present study, we showed that in this new animal model of depression immobility was increased when animals were submitted to the forced swimming test. This finding supports the notion that the amount of immobility during the forced swimming test is directly proportional to a depressive state in the rat.

引用

页码：737 / 739

页数：3

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