INCREASE IN NEUROTENSIN RECEPTOR EXPRESSION IN RAT-BRAIN INDUCED BY CHRONIC TREATMENT WITH THE NONPEPTIDE NEUROTENSIN RECEPTOR ANTAGONIST SR-48692

被引：23

作者：

AZZI, M

NICOT, A

GULLY, D

KITABGI, P

BEROD, A

ROSTENE, W

机构：

[1] HOP ST ANTOINE, INSERM, U339, F-75012 PARIS, FRANCE

[2] SANOFI RECH, F-31036 TOULOUSE, FRANCE

[3] CNRS, IPCM, F-06560 VALBONNE, FRANCE

来源：

NEUROSCIENCE LETTERS | 1994年 / 172卷 / 1-2期

关键词：

NEUROTENSIN RECEPTOR; IN SITU HYBRIDIZATION; VENTRAL MESENCEPHALON; CENTRAL NERVOUS SYSTEM; DOPAMINERGIC NEURON;

D O I：

10.1016/0304-3940(94)90671-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the present study, we examined the regulation of neurotensin receptor following a chronic pharmacological blockade of the neurotensin transmission with a nonpeptide neurotensin receptor antagonist, SR 48692. Our results showed that treatment of the rats for five days with SR 48692, at a dose of 1 mg/kg, i.p., induced an increase of both the number of binding sites for I-125-neurotensin to whole brain membrane homogenates and neurotensin receptor mRNA levels in the ventral mesencephalon. This study brings the first evidence for an in vivo up-regulation of neurotensin receptors following their pharmacological blockade, and suggests that endogenous neurotensin exerts a tonic inhibitory control on neurotensin receptor mRNA levels.

引用

页码：97 / 100

页数：4

共 28 条

[1] HALOPERIDOL BUT NOT CLOZAPINE INCREASES NEUROTENSIN RECEPTOR MESSENGER-RNA LEVELS IN RAT SUBSTANTIA-NIGRA [J].