TOPICAL TIMOLOL WITH AND WITHOUT BENZALKONIUM CHLORIDE - EPITHELIAL PERMEABILITY AND AUTOFLUORESCENCE OF THE CORNEA IN GLAUCOMA

被引:84
作者
DEJONG, C
STOLWIJK, T
KUPPENS, E
DEKEIZER, R
VANBEST, J
机构
[1] Department of Ophthalmology, Leiden University Hospital, Leiden, NL-2333 AA
关键词
D O I
10.1007/BF00184009
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Epithelial permeability and autofluorescence of the cornea were determined by fluorophotometry in 21 patients with open-angle glaucoma or ocular hypertension using timolol medication with the preservative benzalkonium chloride (BAC) and 2 weeks after changing to timolol medication without BAC. The investigation was performed to determine whether removal of BAC would reduce toxic effects on the cornea and complaints of sensations of burning or dry eye. Corneal epithelial permeability decreased significantly after changing medication (mean decrease per patient 27%, P=0.025). Corneal autofluorescence increased significantly after changing medication suggesting an alteration in corneal metabolism (mean increase per patient 6%, P=0.003). Timolol without BAC was found to be as effective as timolol with BAC in reducing intraocular pressure (P=0.4). Removal of BAC from timolol resulted in an improvement of corneal epithelial barrier function and in a reduction of complaints. The improvement was found to be proportional to the duration of the preceding BAC-containing therapy.
引用
收藏
页码:221 / 224
页数:4
相关论文
共 13 条
[1]  
BURSTEIN NL, 1984, INVEST OPHTH VIS SCI, V25, P1453
[2]   INTRINSIC FLUORESCENCE EMISSION FROM CORNEA AT LOW-TEMPERATURES - EVIDENCE OF MITOCHONDRIAL SIGNALS AND THEIR DIFFERING REDOX STATES IN EPITHELIAL AND ENDOTHELIAL SIDES [J].
CHANCE, B ;
LIEBERMAN, M .
EXPERIMENTAL EYE RESEARCH, 1978, 26 (01) :111-117
[3]   MECHANISM OF TIMOLOL IN LOWERING INTRA-OCULAR PRESSURE - IN NORMAL EYE [J].
COAKES, RL ;
BRUBAKER, RF .
ARCHIVES OF OPHTHALMOLOGY, 1978, 96 (11) :2045-2048
[4]   A SIMPLE METHOD FOR DETERMINATION OF CORNEAL EPITHELIAL PERMEABILITY IN HUMANS [J].
DEKRUIJF, EJFM ;
BOOT, JP ;
LATERVEER, L ;
VANBEST, JA ;
RAMSELAAR, JAM ;
OOSTERHUIS, JA .
CURRENT EYE RESEARCH, 1987, 6 (11) :1327-1334
[5]  
FRAUNFELDER FT, 1989, DRUG INDUCED OCULAR, P476
[6]  
KAUFMAN HE, 1980, OPHTHALMOLOGY, V87, P164
[7]   TOPICAL TIMOLOL, CORNEAL EPITHELIAL PERMEABILITY AND AUTOFLUORESCENCE IN GLAUCOMA BY FLUOROPHOTOMETRY [J].
KUPPENS, E ;
STOLWIJK, T ;
VANBEST, J ;
DEKEIZER, R .
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 1994, 232 (04) :215-220
[9]   CORNEAL EPITHELIAL PERMEABILITY AFTER INSTILLATION OF OPHTHALMIC SOLUTIONS CONTAINING LOCAL-ANESTHETICS AND PRESERVATIVES [J].
RAMSELAAR, JAM ;
BOOT, JP ;
VANHAERINGEN, NJ ;
VANBEST, JA ;
OOSTERHUIS, JA .
CURRENT EYE RESEARCH, 1988, 7 (09) :947-950
[10]   CORNEAL AUTOFLUORESCENCE IN DIABETIC AND PENETRATING KERATOPLASTY PATIENTS AS MEASURED BY FLUOROPHOTOMETRY [J].
STOLWIJK, TR ;
VANBEST, JA ;
BOOT, JP ;
OOSTERHUIS, JA .
EXPERIMENTAL EYE RESEARCH, 1990, 51 (04) :403-409