SPECTRUM OF EEG ABNORMALITIES DURING CLOZAPINE TREATMENT

被引:55
作者
MALOW, BA
REESE, KB
SATO, S
BOGARD, PJ
MALHOTRA, AK
SU, TP
PICKAR, D
机构
[1] NINCDS,EEG SECT,BETHESDA,MD 20892
[2] NIMH,EXPTL THERAPEUT BRANCH,BETHESDA,MD
[3] MAINE MED CTR,DEPT PSYCHIAT,PORTLAND,ME
来源
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY | 1994年 / 91卷 / 03期
关键词
CLOZAPINE; EEG; MYOCLONUS; EPILEPTIFORM ABNORMALITIES;
D O I
10.1016/0013-4694(94)90070-1
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Clozapine is a novel antipsychotic agent effective in treating refractory schizophrenia. Clozapine produces fewer extrapyramidal effects than other neuroleptics, although agranulocytosis and seizures are significant adverse effects. To characterize the spectrum of clozapine-related electroencephalographic abnormalities, we identified 10 patients who had electroencephalograms (EEGs) performed before and during clozapine treatment. These 10 patients represented a subset of individuals participating in an investigational trial. During clozapine treatment, five developed myoclonus and one experienced a generalized tonic-clonic seizure. Records were retrospectively reviewed by an electroencephalographer blinded to the patient's history and medications. All patients had normal EEGs before clozapine treatment. While receiving clozapine (250-900 mg daily), all patients developed background slowing in the theta and often delta ranges. Additionally, 7 patients exhibited bilateral spike, polyspike and slow wave discharges, one with a photoparoxysmal response. Follow-up EEGs performed in 4 of these 7 patients after a decrease in clozapine dosage and/or addition in valproic acid showed diminished epileptiform activity.
引用
收藏
页码:205 / 211
页数:7
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