DEVELOPMENT BIOLOGY OF THE RENAL KALLIKREIN-KININ SYSTEM

被引：16

作者：

ELDAHR, SS

机构：

[1] Department of Pediatrics, Division of Pediatric Nephrology, Tulane University School of Medicine, New Orleans, 70112, Louisiana

来源：

PEDIATRIC NEPHROLOGY | 1994年 / 8卷 / 05期

关键词：

ONTOGENY; BRADYKININ RECEPTORS; GENE EXPRESSION; NEPHROGENESIS;

D O I：

10.1007/BF00858150

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Kinins are endothelium-dependent vasodilators and natriuretic paracrine peptides that participate in the regulation of blood pressure, renal hemodynamics and sodium excretion. Several lines of evidence suggest an important role for intrarenal kinins and their receptors in kidney growth and development. (1) The developing rat kidney expresses all the components of the tissue kallikrein-kinin system: tissue kallikrein, low molecular weight (LMW) kininogen, kininase II and kinin receptors. Also, the developing liver expresses high molecular weight and LMW kininogens. Thus, a complete kinin-generating system exists in the developing kidney. (2) Gene transcription, mRNA and protein abundance, and enzymatic activity of renal kallikrein are all markedly up-regulated during postnatal kidney growth, and a positive correlation exists between renal kallikrein synthesis and the maturational rise in renal blood flow. (3) Rat glomerular mesangial cells in culture express the kinin receptors and proliferate in response to bradykinin, suggesting that endogenous kinins and their receptors modulate glomerular growth. (4) The newborn period is characterized by an activation of kinin receptor gene expression, and chronic pharmacological blockade of kinin receptors suppresses DNA synthesis in the developing but not adult kidney. Collectively, these data provide the basis for the hypothesis that endogenous kinins and the kinin receptors play an important role in the developmental biology of the metanephric kidney.

引用

页码：624 / 631

页数：8

共 79 条

[1] Bhoola K.D., Figueroa C.D., Worthy K., Bioregulation of kinins: kallikreins, kininogens, and kininases, Pharmacol Rev, 44, pp. 1-80, (1992)
[2] Carretero O.A., Carbini L.A., Scicli A.G., The molecular biology of the kallikrein-kinin system. I. General description, nomenelature and the mouse gene family, J Hypertens, 11, pp. 693-697, (1993)
[3] Scicli A.G., Carbini L.A., Carretero O.A., The molecular biology of the kallikrein-kinin system. II. The rat gene family, J Hypertens, 11, pp. 775-780, (1993)
[4] Carbini L.A., Scicli A.G., Carretero O.A., The molecular biology of the kallikrein-kinin system. III. The human kallikrein gene family and kallikrein substrate, J Hypertens, 11, pp. 893-898, (1993)
[5] Kitamura N., Takagashi Y., Furuto S., Tanaka T., Nakanishi S., A single gene for bovine high molecular weight and low molecular weight kininogen, Nature, 305, pp. 545-549, (1983)
[6] Proud D., Perkins M., Pierce J.V., Yates K.N., Highet P.F., Herring P.L., Mangkomkanok M., Bahu R., Carone F., Pisano J.J., Characterization and localization of human renal kininogen, J Biol Chem, 256, pp. 10634-10639, (1981)
[7] Iwai N., Matsunaga M., Kita T., Tei M., Kawai C., Detection of low molecular kininogen messenger RNA in human kidney, J Hypertens, 6, pp. S399-S400, (1988)
[8] Figueroa C.D., Maclver A.G., Mackenzie J.C., Bhoola K.D., Localisation of immunoreactive kininogen and tissue kallikrein in the human nephron, Histochemistry, 89, pp. 437-442, (1988)
[9] Okamoto H., Greenbaum L.M., Isolation and structure of T-kinin, Biochem Biophys Res Commun, 112, pp. 701-708, (1983)
[10] Furuto-Kato S., Matsumoto A., Kitamura N., Nakanishi S., Primary structures of the mRNAs encoding the rat precursors for bradykinin and T-kinin, J Biol Chem, 260, pp. 12054-12059, (1983)

← 1 2 3 4 5 6 7 8 →