ENHANCEMENT OF DRUG-INDUCED MOTOR-ACTIVITY BY AN INHIBITOR OF PHENYLETHANOLAMINE-N-METHYLTRANSFERASE

被引：18

作者：

KATZ, RJ

CARROLL, BJ

LEIBLER, L

机构：

[1] Mental Health Research Institute, Department of Psychiatry, University of Michigan, Ann Arbor

来源：

NEUROSCIENCE LETTERS | 1978年 / 8卷 / 01期

关键词：

D O I：

10.1016/0304-3940(78)90102-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The behavioral effects of DCMB (2,3-dichloro-α-methylbenzylamine, Lilly), an inhibitor of brain phenylethanolamine-N-methyltransferase (PNMT; EC 2.1.1.28), were studied in rats and mice. The drug decreased spontaneous motor activity and induced stereotypic gnawing in both species. The motor activity response of rats to d-amphetamine was enhanced after DCMB, and unusual stereotypic head bobbing developed. The stereotypic motor responses of mice to morphine were increased after DCMB. These findings suggest that adrenaline neurons (which project to the extrapyramidal system) are involved in normal motor activity and in the suppression of some forms of stereotypy. © 1978.

引用

页码：83 / 88

页数：6

共 11 条

[1] MONOAMINE MEDIATION OF MORPHINE-INDUCED ACTIVATION OF MICE [J].