ENHANCEMENT OF IGE ANTIBODY-FORMATION IN THE RABBIT BY ADRENERGIC ANTAGONISTS

被引：10

作者：

HOMER, JT ^{[1
]}

CAIN, WA ^{[1
]}

机构：

[1] OKLAHOMA HLTH SCI CTR,DEPT MICROBIOL & IMMUNOL,OKLAHOMA CITY,OK

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY | 1979年 / 59卷 / 02期

关键词：

D O I：

10.1159/000232249

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The effects of adrenergic antagonists on the humoral immune response of rabbits to egg albumin was studied. Propranolol, a β-adrenergic antagonist, when administered at a dosage of 20 mg/kg of body weight, enhanced both passive hemagglutinating and IgE (passive cutaneous anaphylaxis) antibody formation. Phenoxybenzamine, an a-antagonist, at 0.4-40 mg/kg had a similar adjuvant effect. A marked delay in the immune response was noted with high dosages of phenoxybenzamine. Possible mechanisms of the adjuvant effects of these drugs are discussed. © 1979 S. Karger AG, Basel.

引用

页码：121 / 129

页数：9

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