METHODOLOGY OF H-3 SPIPERONE BINDING TO LYMPHOCYTES

被引:15
作者
BONDY, B
ACKENHEIL, M
ENGEL, RR
机构
[1] Psychiatric Hospital, University of Munich, D-8000 Munich 2
关键词
D O I
10.1016/0022-3956(90)90026-M
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Alterations in lymphocyte binding capacity for the dopamine antagonist 3H-spiperone may be of great interest in psychiatric and neurological disorders: an increase in capacity noted in lymphocytes of schizophrenic patients and their families may well turn out to be a phenotypic vulnerability marker. Since the 3H-spiperone binding assay with lymphocytes does not fulfill common receptor-binding assay criteria and depends more on crucial analytical conditions, shortcomings in binding assay might possibly lead to irreproducible results. A detailed methodological description of the binding assay and subsequent calculations has therefore been given in this paper. © 1990.
引用
收藏
页码:83 / 92
页数:10
相关论文
共 26 条
[1]   DETERMINATION OF PROTEIN-LIGAND BINDING CONSTANTS AT EQUILIBRIUM IN BIOLOGICAL SAMPLES [J].
BLONDEAU, JP ;
ROBEL, P .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1975, 55 (02) :375-384
[2]   H-3-SPIPERONE BINDING-SITES IN LYMPHOCYTES AS POSSIBLE VULNERABILITY MARKER IN SCHIZOPHRENIA [J].
BONDY, B ;
ACKENHEIL, M .
JOURNAL OF PSYCHIATRIC RESEARCH, 1987, 21 (04) :521-529
[3]   BINDING OF H-3-SPIPERONE TO HUMAN-LYMPHOCYTES - A BIOLOGICAL MARKER IN SCHIZOPHRENIA [J].
BONDY, B ;
ACKENHEIL, M ;
ELBERS, R ;
FROHLER, M .
PSYCHIATRY RESEARCH, 1985, 15 (01) :41-48
[4]  
BONDY B, 1984, BIOL PSYCHIAT, V19, P1377
[5]  
BONDY B, 1989, EARLY DIAGNOSIS PREV, P205
[6]  
BONDY B, 1988, PHENOTHIAZINES 1 4 B, P791
[7]  
CZLONKOWSKA A, 1987, Brain Behavior and Immunity, V1, P197
[8]  
EBSTEIN RP, 1988, PSYCHOPHARMACOLOGY S, V96, P66
[9]   ARE DOPAMINE-RECEPTORS PRESENT ON HUMAN-LYMPHOCYTES [J].
FLEMINGER, S ;
JENNER, P ;
MARSDEN, CD .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1982, 34 (10) :658-663
[10]  
Leatherbarrow R.J, 1987, ENZFITTER NONLINEAR