DESFERRIOXAMINE AS A LIPID CHAIN-BREAKING ANTIOXIDANT IN SICKLE ERYTHROCYTE-MEMBRANES

被引：54

作者：

HARTLEY, A

DAVIES, M

RICEEVANS, C

机构：

[1] UNIV LONDON,ROYAL FREE HOSP,SCH MED,DEPT BIOCHEM & CHEM,ROWLAND HILL ST,LONDON NW3 2PF,ENGLAND

[2] UNIV YORK,DEPT CHEM,YORK YO1 5DD,N YORKSHIRE,ENGLAND

来源：

FEBS LETTERS | 1990年 / 264卷 / 01期

关键词：

Antioxidant; Desferrioxamine; Electron spin resonance spectroscopy; Iron; Sickle erythrocyte membrane;

D O I：

10.1016/0014-5793(90)80786-I

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mechanism of action of desferrioxamine in the inhibition of the catalysis of iron-induced oxidative damage has been ascribed to its ability to chelate available ferric ion (Kb = 1031). However, recent work has proposed that the trihydroxamate moiety of desferrioxamine can also be involved in electron transfer reactions involving the Superoxide radical, peroxidase/hydrogen peroxide mixtures and ferryl myoglobin radicals. In this study we report evidence for the ability of desferrioxamine to inhibit peroxidative damage to pathological membranes with which non-haem iron is associated through a mechanism of action as a lipid chain breaking antioxidant, independently of its iron chelating properties. © 1990.

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页码：145 / 148

页数：4

相关论文

共 24 条

[1] DENATURED HEMOGLOBIN IN SICKLE ERYTHROCYTES [J].

ASAKURA, T ;

MINAKATA, K ;

ADACHI, K ;

RUSSELL, MO ;

SCHWARTZ, E .

JOURNAL OF CLINICAL INVESTIGATION, 1977, 59 (04) :633-640

[2] QUANTITATIVE STUDIES OF FERRITIN-LIKE IRON IN ERYTHROCYTES OF THALASSEMIA, SICKLE-CELL-ANEMIA, AND HEMOGLOBIN HAMMERSMITH WITH MOSSBAUER-SPECTROSCOPY [J].

BAUMINGER, ER ;

COHEN, SG ;

OFER, S ;

RACHMILEWITZ, EA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (02) :939-943

[3]

CERIOTTI F, 1980, CLIN CHEM, V26, P327

[4] A METHOD FOR THE COMPARATIVE-ASSESSMENT OF ANTIOXIDANTS AS PEROXYL RADICAL SCAVENGERS [J].

DARLEYUSMAR, VM ;

HERSEY, A ;

GARLAND, LG .

BIOCHEMICAL PHARMACOLOGY, 1989, 38 (09) :1465-1469

[5] DETECTION OF PEROXYL AND ALKOXYL RADICALS PRODUCED BY REACTION OF HYDROPEROXIDES WITH HEME-PROTEINS BY ELECTRON-SPIN RESONANCE SPECTROSCOPY [J].

DAVIES, MJ .

BIOCHIMICA ET BIOPHYSICA ACTA, 1988, 964 (01) :28-35

[6] DESFERRIOXAMINE (DESFERAL) AND SUPEROXIDE FREE-RADICALS - FORMATION OF AN ENZYME-DAMAGING NITROXIDE [J].

DAVIES, MJ ;

DONKOR, R ;

DUNSTER, CA ;

GEE, CA ;

JONAS, S ;

WILLSON, RL .

BIOCHEMICAL JOURNAL, 1987, 246 (03) :725-729

[7] PREPARATION AND CHEMICAL CHARACTERISTICS OF HEMOGLOBIN-FREE GHOSTS OF HUMAN ERYTHROCYTES [J].

DODGE, JT ;

HANAHAN, DJ ;

MITCHELL, C .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1963, 100 (01) :119-&

[8] A METHOD FOR REMOVAL OF TRACE IRON CONTAMINATION FROM BIOLOGICAL BUFFERS [J].

GUTTERIDGE, JMC .

FEBS LETTERS, 1987, 214 (02) :362-364

[9] THE NATURE OF MEMBRANE-BOUND IRON-SPECIES INVOLVED IN RADICAL-MEDIATED DAMAGE TO SICKLE ERYTHROCYTES [J].

HARTLEY, A ;

RICEEVANS, C .

BIOCHEMICAL SOCIETY TRANSACTIONS, 1989, 17 (03) :488-489

[10] MEMBRANE-ASSOCIATED IRON-SPECIES AND MEMBRANE OXIDATION IN SICKLE-CELL DISEASE [J].

HARTLEY, A ;

RICEEVANS, C .

BIOCHEMICAL SOCIETY TRANSACTIONS, 1989, 17 (01) :116-118