SYNTHESIS AND REACTIONS OF 2-MERCAPTO-4-ARYL 4H-1,2,3,4,5,6-HEXAHYDRO-BENZO[H]QUINAZOLINES

被引：5

作者：

HAMMAM, AEG ^{[1
]}

HUSSAIN, SM ^{[1
]}

KOTOB, IR ^{[1
]}

机构：

[1] CAIRO UNIV,DEPT CHEM,CAIRO,EGYPT

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1990年 / 47卷 / 1-2期

关键词：

Mercapto-benzoquinazolines; thiazino-benzoquinazolines; thiazolo-benzoquinazolines;

D O I：

10.1080/10426509008046845

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

2-Mercapto-4-aryl-4H-l, 2, 3, 4, 5, 6-hexahydrobenzo[b)quinazolines (2) have been synthesized. Compounds 2 reacted with chloroacetic acid, 2-bromopropanoic acid or 3-bromopropanoic acid in the presence of fused sodium acetate and acetic anhydride to give 5-arvl-SH-2.3.6.7-tetrahydrobenzo[h]thiazolo[2, 3-b]quinazoline-3-ones (3), their 2-methyl derivatives (5) and 6-arvl-6H-2, 3, 7, 8-tetrahydrobenzo[b]-l, 3-thiazine-[2, 3-b]quinazoline-4-ones (6), respectively. 2-(Arylmethyl-ene)-5-aryl-5H-2, 3, 6, 7-tetrahydrobenzo[h]thiazolo[2, 3-b]quinazoline-3-ones (4) were prepared by the reaction of compounds 2 with chloroacetic acid, and aromatic aldehydes in presence of fused sodium acetate and acetic anhydride or by the reactions of compounds 3 with aromatic aldehydes in the presence of acetic anhydride. © 1990, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：47 / 51

页数：5

共 13 条

[1] REACTIONS WITH (ARYLMETHYLENE)CYCLOALKANONES .2. SYNTHESIS OF 10-(ARYLMETHYLENE)HEXAHYDROCYCLOHEPTENO[1,2-D]-THIAZOLO[3,2-A]PYRIMIDIN-3-ONE DERIVATIVES OF PROBABLE ANTI-CANCER ACTIVITY [J].