Genetic analysis of picornaviruses

被引:15
作者
Kirkegaard, Karla [1 ,2 ]
机构
[1] Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA
[2] Univ Colorado, Howard Hughes Med Inst, Boulder, CO 80309 USA
基金
美国国家卫生研究院;
关键词
defective interfering; DI; terminal uridylyl transferase; TUTase;
D O I
10.1016/S0959-437X(05)80324-7
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
During the past year, genetic studies of picornaviruses, vastly facilitated by the application of infectious picornaviral cDNAs and RNAs, have contributed to our understanding of the function of individual picornavirus polypeptides and to the genetic processes that operate in these small RNA viruses. Especially notable were the demonstrations that the RNA-dependent RNA polymerase may have a function in RNA synthesis as an uncleaved precursor polypeptide, and that a mutation in the polymerase can be complemented in trans, in contrast to data obtained from previously studied polymerase mutants. A new in vitro system, in which positive-strand sythesis, negative-strand synthesis and RNA packaging were all observed, will facilitate further studies into the mechanism of these processes.
引用
收藏
页码:64 / 70
页数:7
相关论文
共 51 条
[1]   SUBSTITUTIONS IN THE PROTEASE (3CPRO) GENE OF POLIOVIRUS CAN SUPPRESS A MUTATION IN THE 5' NONCODING REGION [J].
ANDINO, R ;
RIECKHOF, GE ;
TRONO, D ;
BALTIMORE, D .
JOURNAL OF VIROLOGY, 1990, 64 (02) :607-612
[2]   A FUNCTIONAL RIBONUCLEOPROTEIN COMPLEX FORMS AROUND THE 5' END OF POLIOVIRUS RNA [J].
ANDINO, R ;
RIECKHOF, GE ;
BALTIMORE, D .
CELL, 1990, 63 (02) :369-380
[4]   GENETIC COMPLEMENTATION AMONG POLIOVIRUS MUTANTS DERIVED FROM AN INFECTIOUS CDNA CLONE [J].
BERNSTEIN, HD ;
SARNOW, P ;
BALTIMORE, D .
JOURNAL OF VIROLOGY, 1986, 60 (03) :1040-1049
[5]   TRANS RESCUE OF A MUTANT POLIOVIRUS RNA-POLYMERASE FUNCTION [J].
CHARINI, WA ;
BURNS, CC ;
EHRENFELD, E ;
SEMLER, BL .
JOURNAL OF VIROLOGY, 1991, 65 (05) :2655-2665
[6]   EXPRESSION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) GAG, POL, AND ENV PROTEINS FROM CHIMERIC HIV-1-POLIOVIRUS MINIREPLICONS [J].
CHOI, WS ;
PALGHOSH, R ;
MORROW, CD .
JOURNAL OF VIROLOGY, 1991, 65 (06) :2875-2883
[7]   MYRISTYLATION OF PICORNAVIRUS CAPSID PROTEIN VP4 AND ITS STRUCTURAL SIGNIFICANCE [J].
CHOW, M ;
NEWMAN, JFE ;
FILMAN, D ;
HOGLE, JM ;
ROWLANDS, DJ ;
BROWN, F .
NATURE, 1987, 327 (6122) :482-486
[8]   A TRANSCRIPTIONALLY ACTIVE FORM OF TFIIIC IS MODIFIED IN POLIOVIRUS-INFECTED HELA-CELLS [J].
CLARK, ME ;
DASGUPTA, A .
MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (10) :5106-5113
[9]   HEPATITIS-A VIRUS CDNA AND ITS RNA TRANSCRIPTS ARE INFECTIOUS IN CELL-CULTURE [J].
COHEN, JI ;
TICEHURST, JR ;
FEINSTONE, SM ;
ROSENBLUM, B ;
PURCELL, RH .
JOURNAL OF VIROLOGY, 1987, 61 (10) :3035-3039
[10]   ENCEPHALOMYOCARDITIS VIRUS-RNA POLYMERASE PREPARATIONS, WITH AND WITHOUT RNA HELICASE ACTIVITY [J].
DMITRIEVA, TM ;
NORKINA, KB ;
AGOL, VI .
JOURNAL OF VIROLOGY, 1991, 65 (05) :2714-2717