THE EFFECT OF VERAPAMIL ON THE THERMOREGULATORY RESPONSES PRODUCED BY ENDOTOXIN OR NORADRENALINE IN RABBITS

被引：2

作者：

GAGALO, IT

HAC, EE

机构：

[1] Department of Pharmacology, Medical Academy, 80-227 Gdańsk 6

来源：

GENERAL PHARMACOLOGY | 1991年 / 22卷 / 05期

关键词：

D O I：

10.1016/0306-3623(91)90234-W

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Thermal responses to verapamil (5 mg/kg per hr) were investigated in pyrogen (lipopolysaccharide Escherichia coli) or nonadrenaline (NA) treated rabbits. 2. The compound reduced the pyretic, metabolic and vasoconstricting activity of pyrogen. 3. On the other hand, verapamil did not significantly affect NA-induced hyperthermia. 4. Possible mechanisms responsible for the thermoregulatory activity of verapamil are discussed.

引用

页码：939 / 942

页数：4

共 19 条

[1] SHORT-TERM AND LONG-TERM EFFECTS OF CALCIUM ENTRY BLOCKERS ON THE KIDNEY [J].