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CHROMOSOME REARRANGEMENT IN LEISHMANIA-MEXICANA M379

被引：21
作者：
LIU, JH
GAJENDRAN, N
MUTHUI, D
MUYLDERMANS, S
DUJARDIN, JC
DEDONCKER, S
JACQUET, D
LERAY, D
MATHIEUDAUDE, F
HAMERS, R
机构：
[1] VRIJE UNIV BRUSSELS, INST MOLEC BIOL, 65 PAARDENSTR, B-1640 RHODE ST GENESE, BELGIUM
[2] INST TROP GENEESKUNDE, ANTWERP, BELGIUM
[3] ORSTOM, GENET PARASITES & VECTEURS LAB, MONTPELLIER, FRANCE
来源：
MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1991年 / 46卷 / 01期
关键词：
LEISHMANIA-MEXICANA M379; CIRCULAR EXTRACHROMOSOMAL ELEMENT; CIRCULARIZATION; LINEARIZATION; CHROMOSOME REARRANGEMENT;
D O I：
10.1016/0166-6851(91)90198-F
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Circular extrachromosomal elements were observed in a variety of Leishmania species. We show here that two lines originating from the same isolate have been found to contain a circular DNA molecule of 26.6 kb and a linear chromosome of about 250 kb, respectively, which share a homology of more than 20 kb. The circular DNA molecule and its related region on the linear chromosome were cloned and their restriction maps compared. This investigation reveals information about chromosome rearrangement in L. mexicana M379. Further examination will enable us to understand the nature of chromosome rearrangement such as circularization or linearization.
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页码：53 / 60
页数：8
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