METAL-BINDING SITES IN PROTEINS

被引：126

作者：

TAINER, JA ^{[1
]}

ROBERTS, VA ^{[1
]}

GETZOFF, ED ^{[1
]}

机构：

[1] SCRIPPS RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 1991年 / 2卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0958-1669(91)90084-I

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A dramatic increase in the number of solved metalloprotein structures and recent breakthroughs in structural analysis have provided a sufficiently detailed understanding of the structural chemistry of some metal-binding sites to allow successful design. As a result, metal-binding site design is now one of the most powerful and promising approaches for influencing protein folding, assembly, stability and catalysis.

引用

页码：582 / 591

页数：10

共 52 条

[1]

ADMAN ET, 1991, ADV PROTEIN CHEM, V42, P145

[2] SYNTHESIS AND CHARACTERIZATION OF A RECOMBINANT MYOHEMERYTHRIN PROTEIN ENCODED BY A SYNTHETIC GENE [J].

ALEXANDER, H ;

ALEXANDER, S ;

HEFFRON, F ;

FIESER, TM ;

HAY, BN ;

GETZOFF, ED ;

TAINER, JA ;

LERNER, RA .

GENE, 1991, 99 (02) :151-156

[3]

ARMSTRONG WH, 1988, ACS SYM SER, V372, P1

[4]

BERG JM, 1990, ANNU REV BIOPHYS BIO, V19, P405

[5] 3-DIMENSIONAL STRUCTURES OF COMPLEXES OF LATHYRUS-OCHRUS ISOLECTIN-I WITH GLUCOSE AND MANNOSE - FINE SPECIFICITY OF THE MONOSACCHARIDE-BINDING SITE [J].

BOURNE, Y ;

ROUSSEL, A ;

FREY, M ;

ROUGE, P ;

FONTECILLACAMPS, JC ;

CAMBILLAU, C .

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 1990, 8 (04) :365-376

[6] MOLECULAR-STRUCTURE OF LEUCINE AMINOPEPTIDASE AT 2.7-A RESOLUTION [J].

BURLEY, SK ;

DAVID, PR ;

TAYLOR, A ;

LIPSCOMB, WN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (17) :6878-6882

[7] CALCIUM-BINDING SITES IN TOMATO BUSHY STUNT VIRUS VISUALIZED BY LAUE CRYSTALLOGRAPHY [J].

CAMPBELL, JW ;

CLIFTON, IJ ;

GREENHOUGH, TJ ;

HAJDU, J ;

HARRISON, SC ;

LIDDINGTON, RC ;

SHRIVE, AK .

JOURNAL OF MOLECULAR BIOLOGY, 1990, 214 (03) :627-632

[8] SYSTEMATICS IN THE INTERACTION OF METAL-IONS WITH THE MAIN-CHAIN CARBONYL GROUP IN PROTEIN STRUCTURES [J].

CHAKRABARTI, P .

BIOCHEMISTRY, 1990, 29 (03) :651-658

[9] GEOMETRY OF INTERACTION OF METAL-IONS WITH HISTIDINE-RESIDUES IN PROTEIN STRUCTURES [J].

CHAKRABARTI, P .

PROTEIN ENGINEERING, 1990, 4 (01) :57-63

[10] INTERACTION OF METAL-IONS WITH CARBOXYLIC AND CARBOXAMIDE GROUPS IN PROTEIN STRUCTURES [J].

CHAKRABARTI, P .

PROTEIN ENGINEERING, 1990, 4 (01) :49-56

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