FETAL TOXICITY OF NITROPRUSSIDE IN THE PREGNANT EWE

被引：75

作者：

NAULTY, J ^{[1
]}

CEFALO, RC ^{[1
]}

LEWIS, PE ^{[1
]}

机构：

[1] NATL NAVAL MED CTR, BETHESDA, MD 20014 USA

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 1981年 / 139卷 / 06期

关键词：

D O I：

10.1016/0002-9378(81)90492-0

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Sodium nitroprusside, a direct-acting vasodilator, is used to treat the hypertension associated with preeclampsia and eclampsia. Fatal cyanide intoxication occurs during infusion of nitroprusside. Placental transfer and fetal toxicity of nitroprusside were investigated in the acute pregnant ewe model. A maternal i.v. infusion of nitroprusside solution was maintained at a rate sufficient to decrease mean maternal arterial pressure by 20% for 1 h. Maternal and fetal levels of nitroprusside were in equilibrium at the 20 min sample. Of the 8 animals, 5 exhibited tachyphylaxis to nitroprusside, and their fetuses died in utero with lethal levels of cyanide. No significant changes were observed in uterine blood flow.

引用

页码：708 / 711

页数：4

共 14 条

[1]

BOXER GE, 1951, ARCH BIOCHEM, V30, P372

[2] PREVENTION OF NITROPRUSSIDE-INDUCED CYANIDE TOXICITY WITH HYDROXOCOBALAMIN [J].