ETHAMBUTOL INHIBITION OF GLUCOSE-METABOLISM IN MYCOBACTERIA - A POSSIBLE TARGET OF THE DRUG

被引：23

作者：

SILVE, G ^{[1
]}

VALEROGUILLEN, P ^{[1
]}

QUEMARD, A ^{[1
]}

DUPONT, MA ^{[1
]}

DAFFE, M ^{[1
]}

LANEELLE, G ^{[1
]}

机构：

[1] UNIV P SABATIER,DEPT GLYCOCONJUGUES & BIOMEMBRANES,PHARMACOL & TOXICOL FONDAMENTALES LAB,CNRS,F-31062 TOULOUSE,FRANCE

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1993年 / 37卷 / 07期

关键词：

D O I：

10.1128/AAC.37.7.1536

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The addition Of D-arabinose, D-galactose, D-glucosamine, or D-mannose to the growth medium of Mycobacterium smegmatis suppressed the inhibitory effects of ethambutol both on acetate labeling of cell wall-linked mycolic acids and on the increase in the delipidated cell dry weight. The addition Of D-glucose or D-fructose had no effect. It is proposed that ethambutol inhibits an early step of glucose conversion into the monosaccharides used for the biosynthesis of structurally and biologically important cell wall polysaccharides: arabinogalactan, arabinomannan, and peptidoglycan.

引用

页码：1536 / 1538

页数：3

共 16 条

[1]

CHEEMA S, 1985, IRCS MED SCI-BIOCHEM, V13, P843

[2] SPECIFIC LIPIDS FROM MYCOBACTERIUM-ULCERANS [J].