NOVEL APPROACHES TO LINKAGE MAPPING

被引：54

作者：

SHEFFIELD, VC ^{[1
]}

NISHIMURA, DY ^{[1
]}

STONE, EM ^{[1
]}

机构：

[1] UNIV IOWA, DEPT OPHTHALMOL, IOWA CITY, IA 52242 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1995年 / 5卷 / 03期

关键词：

D O I：

10.1016/0959-437X(95)80048-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The recent progress seen in the development of high-quality genetic markers and high-density human genetic maps is facilitating new strategies for mapping disease-causing and disease-susceptibility genes. These strategies, which include homozygosity mapping, DNA pooling, and the utilization of linkage disequilibrium, have been successfully applied to the mapping and fine mapping of several loci causing diseases segregating in genetically isolated populations.

引用

页码：335 / 341

页数：7

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