TOTAL ANTIOXIDANT CAPACITY OF SEMINAL PLASMA IS DIFFERENT IN FERTILE AND INFERTILE MEN

被引:264
作者
LEWIS, SEM [1 ]
BOYLE, PM [1 ]
MCKINNEY, KA [1 ]
YOUNG, IS [1 ]
THOMPSON, W [1 ]
机构
[1] QUEENS UNIV BELFAST,INST CLIN SCI,DEPT CLIN BIOCHEM,BELFAST BT12 6BA,ANTRIM,NORTH IRELAND
关键词
ANTIOXIDANT CAPACITY; REACTIVE OXYGEN SPECIES; SPERM; MALE INFERTILITY;
D O I
10.1016/S0015-0282(16)57870-4
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To determine if the total antioxidant capacity of seminal plasma is different in fertile and infertile men. Design: An enhanced chemiluminescence assay applied to seminal plasma from groups of fertile and infertile men. Setting: The Assisted Conception Unit, Royal Maternity Hospital, Belfast. Subjects: Men of proven fertility whose partners had an ongoing pregnancy resulting from IVF and male partners of couples attending our subfertility clinic. Results: Total antioxidant capacity was significantly higher in seminal plasma from fertile men than from that of infertile men with normozoospermic samples that exhibited reactive oxygen species or asthenozoospermic samples with or without reactive oxygen species activity. Conclusions: Seminal plasma from infertile men has lower antioxidant levels than that of fertile men, particularly of patients whose semen have poor sperm motility. The presence of reactive oxygen species activity in sperm of infertile groups also is associated with lower levels of chain-breaking antioxidants in seminal plasma.
引用
收藏
页码:868 / 870
页数:3
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