THE EFFECT OF FOOD ON THE GASTROINTESTINAL TRANSIT AND SYSTEMIC ABSORPTION OF NAPROXEN FROM A NOVEL SUSTAINED-RELEASE FORMULATION

被引:31
作者
KENYON, CJ
HOOPER, G
TIERNEY, D
BUTLER, J
DEVANE, J
WILDING, IR
机构
[1] PHARMACEUT PROFILES LTD,NOTTINGHAM NG7 2QP,ENGLAND
[2] ELAN CORP PLC,ATHLONE,IRELAND
关键词
PHARMACOSCINTIGRAPHY; SUSTAINED RELEASE; NAPROXEN; FOOD; BIOAVAILABILITY;
D O I
10.1016/0168-3659(94)00118-E
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The in vivo behaviour of a novel sustained release formulation of naproxen was investigated using gamma scintigraphy in eight healthy male volunteers under fasted and fed conditions. Disintegration of the tablet into discrete sustained release pellets occurred in the stomach shortly after administration. Feeding resulted in a lag time prior to the onset of gastric emptying but food did not affect transit through the small intestine. Post-prandial administration of the sustained release formulation did not affect the disintegration of the tablet or the bioavailability of the drug.
引用
收藏
页码:31 / 36
页数:6
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