CYCASIN - DETECTION OF ASSOCIATED MUTAGENIC ACTIVITY IN VIVO

被引：34

作者：

GABRIDGE, MG

DENUNZIO, A

LEGATOR, MS

机构：

[1] Cell Biology Branch, Division of Nutrition, Department of Health, Education, and Welfare, Washington

[2] Department of Microbiology, University of Michigan, Ann Arbor

来源：

SCIENCE | 1969年 / 163卷 / 3868期

关键词：

D O I：

10.1126/science.163.3868.689

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cycasin and its lagycone, methylazoxymethanol, increase the mutant frequency of Salmonella typhimurium histidine auxotrophs when tested in the host-mediated assay. As expected, the degree of cycasin-related mutagenic activity depends on the facility with which the compound can be enzymatically deglucosylated by the normal intestinal flora.

引用

页码：689 / &

共 10 条

[1]

GABRIDGE MG, IN PRESS

[2]

KOBAYASHI A, 1964, FED PROC, V23, P1354

[3]

LAQUEUR GL, 1966, JNCI-J NATL CANCER I, V37, P217

[4]

LAQUEUR GL, 1964, FED PROC, V23, P1386

[5]