INDUCTION OF ARYL-HYDROCARBON HYDROXYLASE-ACTIVITY AND PULMONARY-CARCINOMA

被引：49

作者：

GAHMBERG, CG ^{[1
]}

SEKKI, A ^{[1
]}

KOSUNEN, TU ^{[1
]}

HOLSTI, LR ^{[1
]}

MAKELA, O ^{[1
]}

机构：

[1] UNIV HELSINKI,DEPT THERAPEUT RADIOL,SF-00290 HELSINKI 29,FINLAND

来源：

INTERNATIONAL JOURNAL OF CANCER | 1979年 / 23卷 / 03期

关键词：

D O I：

10.1002/ijc.2910230305

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aryl hydrocarbon hydroxylase activity in lymphoblasts from normal Finnish adults and from patients with pulmonary carcinomas and other types of malignancy has been studied by a modification of previously used techniques. High absolute induced aryl hydrocarbon hydroxylase activity was found in 39% of patients with untreated lung cancer but only in 15% of normal people. No increased frequency was found in the control group comprising other malignancies. The diagnosis of pulmonary carcinoma was made at a lower mean age (4.9 years younger) in the individuals with high aryl hydrocarbon hydroxylase activity than in those with low activity. High absolute aryl hydrocarbon hydroxylase activity was dominantly inherited in normal individuals, and the frequency of the Ahb gene in the Finnish population was 8%. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：302 / 305

页数：4

共 17 条

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