SPECIFIC INTERACTION BETWEEN FOLLITROPIN AND GM1 GANGLIOSIDE INCORPORATED INTO LIPID-MEMBRANES

被引：16

作者：

DELEERS, M

CHATELAIN, P

POSS, A

RUYSSCHAERT, JM

机构：

[1] Laboratoire de Chimie Physique des Macromolécules aux Interfaces, Université Libre de Bruxelles, Bruxelles

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 89卷 / 04期

关键词：

D O I：

10.1016/0006-291X(79)92121-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A specific interaction was demonstrated between a monosialo-ganglioside (galactosyl-N-acetylgalactosaminyl-(N-acetylneuraminyl)-galactosylglucosylceramide) incorporated in glycerol monoleate planar bilayer membranes and follitropin. Conductance of glycerol monoleate planar bilayer membranes containing gangliosides were measured before and after addition of follitropin in the aqueous phase. A 5 fold increase of membrane conductance was observed in presence of a specific monosialo-ganglioside. No significant effect was obtained with di- and trisialogangliosides. Membrane conductance changes were suppressed by the presence of an equimolar mixture of the saccharide residues (galactose, N-acetylgalactosamine and N-acetylneuraminic acid) present in the hydrophilic moeity of the ganglioside. The results favour the hypothesis that gangliosides may contribute to the formation of functional glycoproteins receptors. © 1979.

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页码：1102 / 1106

页数：5

相关论文

共 12 条

[1] SPECIFIC GT1 GANGLIOSIDE-LUTEINIZING HORMONE INTERACTION INDUCES CONDUCTANCE CHANGES IN LIPID BILAYERS [J].

CHATELAIN, P ;

DELEERS, M ;

POSS, A ;

RUYSSCHAERT, JM .

EXPERIENTIA, 1979, 35 (03) :334-335

[2] SPECIFIC INTERACTION BETWEEN CONCANAVALIN A AND GLYCOLIPIDS INCORPORATED INTO PLANAR BILAYER MEMBRANES [J].

DELEERS, M ;

POSS, A ;

RUYSSCHAERT, JM .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1976, 72 (02) :709-713

[3] EFFECTS OF THYROTROPIN ON THYROID CELL-MEMBRANE - HYPERPOLARIZATION INDUCED BY HORMONE-RECEPTOR INTERACTION [J].

GROLLMAN, EF ;

LEE, G ;

AMBESIIMPIOMBATO, FS ;

MELDOLESI, MF ;

ALOJ, SM ;

COON, HG ;

KABACK, HR ;

KOHN, LD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (06) :2352-2356

[4] SEQUENCE SIMILARITY BETWEEN CHOLERA TOXIN AND GLYCOPROTEIN HORMONES - IMPLICATIONS FOR STRUCTURE ACTIVITY RELATIONSHIP AND MECHANISM OF ACTION [J].

LEDLEY, FD ;

MULLIN, BR ;

LEE, G ;

ALOJ, SM ;

FISHMAN, PH ;

HUNT, LT ;

DAYHOFF, MO ;

KOHN, LD .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1976, 69 (04) :852-859

[5] INTERACTION BETWEEN VESICLES CONTAINING GANGLIOSIDES AND LECTINS - LIMULIN AND WHEAT-GERM AGGLUTININ [J].

MAGETDANA, R ;

ROCHE, AC ;

MONSIGNY, M .

FEBS LETTERS, 1977, 79 (02) :305-309

[6]

Mullin B. R., 1977, SCIENCE, V199, P77

[7] THYROTROPIN-GANGLIOSIDE INTERACTIONS AND THEIR RELATIONSHIP TO STRUCTURE AND FUNCTION OF THYROTROPIN RECEPTORS [J].

MULLIN, BR ;

FISHMAN, PH ;

LEE, G ;

ALOJ, SM ;

LEDLEY, FD ;

WINAND, RJ ;

KOHN, LD ;

BRADY, RO .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (03) :842-846

[8] EVIDENCE FOR A SPECIFIC INTERACTION BETWEEN GT1 GANGLIOSIDE INCORPORATED INTO BILAYER MEMBRANES AND THYROTROPIN [J].

POSS, A ;

DELEERS, M ;

RUYSSCHAERT, JM .

FEBS LETTERS, 1978, 86 (02) :160-162

[9] CORRELATION BETWEEN LATERAL LIPID PHASE SEPARATION AND IMMUNOLOGICAL RECOGNITION IN SENSITIZED LIPOSOMES [J].

RUYSSCHAERT, JM ;

TENENBAUM, A ;

BERLINER, C ;

DELMELLE, M .

FEBS LETTERS, 1977, 81 (02) :406-410

[10] MODEL FOR GANGLIOSIDE BEHAVIOR IN CELL-MEMBRANES [J].

SHAROM, FJ ;

GRANT, CWM .

BIOCHIMICA ET BIOPHYSICA ACTA, 1978, 507 (02) :280-293