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ATTENUATED SALMONELLA AS LIVE VACCINES - PROSPECTS FOR MULTIVALENT POULTRY VACCINES

被引：14
作者：
GRIFFIN, HG
机构：
[1] Division of Molecular Biology, AFRC Institute for Animal Health, Houghton Laboratory, Houghton, Huntingdon, Cambridgeshire
来源：
WORLDS POULTRY SCIENCE JOURNAL | 1991年 / 47卷 / 02期
关键词：
SALMONELLA; VACCINE; COCCIDIOSIS; INFECTIOUS LARYNGOTRACHEITIS VIRUS; RECOMBINANT DNA; ATTENUATION;
D O I：
10.1079/WPS19910014
中图分类号：
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号：
0905 ;
摘要：
Live attenuated strains of Salmonella spp. make excellent vaccines against salmonellosis in experimental animals, eliciting a cell-mediated, mucosal and humoral immune response. In addition, new recombinant DNA technology permits the expression in Salmonella strains of protective antigens from unrelated bacterial, viral or parasitic pathogens. Exciting possibilities exist for a single live vaccine which could provide protection against two or more infectious agents. Recently, attenuated strains of the chicken pathogen Salmonella gallinarum have been considered as the basis of a live multivalent poultry vaccine and work is progressing on the expression of coccidial and herpes viral antigens in strains of Salmonella.
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页码：129 / 140
页数：12
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