HUMAN DOPA DECARBOXYLASE - LOCALIZATION TO HUMAN CHROMOSOME-7P11 AND CHARACTERIZATION OF HEPATIC CDNAS

被引：26

作者：

SCHERER, LJ

MCPHERSON, JD

WASMUTH, JJ

MARSH, JL

机构：

[1] UNIV CALIF IRVINE,CTR DEV BIOL,IRVINE,CA 92717

[2] UNIV CALIF IRVINE,DEPT BIOL CHEM,IRVINE,CA 92717

[3] UNIV CALIF IRVINE,DEPT DEV & CELL BIOL,IRVINE,CA 92717

来源：

GENOMICS | 1992年 / 13卷 / 02期

关键词：

D O I：

10.1016/0888-7543(92)90275-W

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have cloned full-length DDC cDNAs from a human hepatoma cDNA library [DDC; dopa decarboxylase; aromatic-L-amino acid decarboxylase, EC 4.1.1.28]. The protein encoded by hepatoma cells is the same as that encoded by adrenal chromaffin derived pheochromocytoma cells, despite reported differences in biochemical properties. We have confirmed the location of the DDC gene to chromosome 7 using a new panel of somatic cell hybrids, and we have localized the gene to band p11 on chromosome 7 by fluorescent in situ hybridization. The human gene retains 65% amino acid identity with Drosophila DDC (Accession No. X04426) and considerable structural similarity with other enzymes (F.R. Jackson, 1990, J. Mol. Evol. 31: 325-329, and references therein). © 1992.

引用

页码：469 / 471

页数：3

共 10 条

[1]

BRUNEAU G, 1990, ANN GENET-PARIS, V33, P208

[2]

COOPER JR, 1986, BIOCH BASIS NEUROPHA, P309

[3] LINKAGE OF THE LEUS, EMTB, AND CHR GENES ON CHROMOSOME-5 IN HUMANS AND EXPRESSION OF HUMAN GENES ENCODING PROTEIN SYNTHETIC COMPONENTS IN HUMAN CHINESE-HAMSTER HYBRIDS [J].