SPLITTING OF CIS-SYN CYCLOBUTANE THYMINE-THYMINE DIMERS BY RADIOLYSIS AND ITS RELEVANCE TO ENZYMATIC PHOTOREACTIVATION

被引：40

作者：

HEELIS, PF ^{[1
]}

DEEBLE, DJ ^{[1
]}

KIM, ST ^{[1
]}

SANCAR, A ^{[1
]}

机构：

[1] UNIV N CAROLINA,DEPT BIOCHEM,CHAPEL HILL,NC 27599

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 1992年 / 62卷 / 02期

关键词：

D O I：

10.1080/09553009214551941

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Cs-137-gamma-irradiation of cis-syn thymine-thymine cyclobutane type dimers has been studied in aqueous solution. The mechanism of thymine dimer cleavage by e(aq)-, CO2.-, OH.,SO4.-, Br2.-, and isopropanol radicals was studied using high pressure liquid chromatography (HPLC). Evidence that the one-electron reductants studied induce dimer cleavage partially by a chain reaction is presented. Approximate values for the one-electron reduction potential of thymine-thymine are obtained and thermodynamic calculations are presented in order to predict the direction of electron transfer in the case of enzymatic photoreactivation.

引用

页码：137 / 143

页数：7

共 34 条

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