LARGE-SCALE PREPARATION OF N,N'-DIACETYLCHITOBIOSE BY ENZYMATIC DEGRADATION OF CHITIN AND ITS CHEMICAL MODIFICATIONS

被引：36

作者：

TERAYAMA, H

TAKAHASHI, S

KUZUHARA, H

机构：

[1] INST PHYS & CHEM RES,WAKO,SAITAMA 35101,JAPAN

[2] SAITAMA UNIV,GRAD SCH SCI & ENGN,URAWA,SAITAMA 338,JAPAN

来源：

JOURNAL OF CARBOHYDRATE CHEMISTRY | 1993年 / 12卷 / 01期

关键词：

D O I：

10.1080/07328309308018542

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hundred gram quantities of peracetylated chitobiose were prepared by degradation of colloidal chitin with commercially available chitinase (EC 3.2.1.14) from Streptomyces griseus and subsequent acetylation, the product being readily convertible into N,N'-diacetylchitobiose by conventional de-O-acetylation. These chitobiose derivatives were subjected to further chemical modifications to give novel disaccharide derivatives composed of a pair of 2-acetamido-2-deoxy-D-allopyranose moieties that are potential intermediates for the synthesis of an enzyme inhibitor.

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页码：81 / 93

页数：13

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