LACK OF THE STEROID 15-ALPHA-HYDROXYLASE GENE (CYP2A-4) IN WILD MOUSE STRAIN MUS-SPRETUS - RAPID EVOLUTION OF THE P450 GENE SUPERFAMILY

被引：10

作者：

AIDA, K ^{[1
]}

MOORE, R ^{[1
]}

NEGISHI, M ^{[1
]}

机构：

[1] NIEHS, REPROD & DEV TOXICOL LAB, PHARMACOGENET SECT, RES TRIANGLE PK, NC 27709 USA

来源：

GENOMICS | 1994年 / 19卷 / 03期

关键词：

D O I：

10.1006/geno.1994.1107

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Steroid 15 alpha-hydroxylase P450(15 alpha) and coumarin 7-bydroxylase P450coh genes Cyp2a-4 and Cyp2a-5 are members of the mouse P450 2A subfamily. Whereas Mus musclus domesticus strains contain both genes, wild mouse strain Mus spretus contains only Cyp2a-5. Evolutionarily, therefore, Cyp2a-5 is ancestral to Cyp2a-4. Moreover, the line to Cyp2a-4 descended as recently as 3 million years ago in an ancestral mouse. This evidence implies a rapid evolution of the P450 gene superfamily. (C) 1994 Academic Press, Inc.

引用

页码：564 / 566

页数：3

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