DOWN-REGULATION OF THE HUMAN C-FOS AND C-MYC PROTOONCOGENE PROMOTERS BY ADENOASSOCIATED VIRUS REP78

被引：67

作者：

HERMONAT, PL ^{[1
]}

机构：

[1] UNIV ARKANSAS MED SCI HOSP,DEPT MICROBIOL & IMMUNOL,LITTLE ROCK,AR 72205

来源：

CANCER LETTERS | 1994年 / 81卷 / 02期

关键词：

C-FAS; C-MYC; ADENOASSOCIATED VIRUS; REP78; ANTIONCOGENE;

D O I：

10.1016/0304-3835(94)90193-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Adeno-associated virus (AAV) is a non-pathogenic human parvovirus which has anti-tumor and anti-proliferation properties in tissue culture and animal studies. Furthermore, AAV infection is negatively associated with human cervical cancer. C-myc has been implicated in cervical cancer, and c-fos is involved in signal transduction initiation of cell growth. To study the potential regulation of these two prominent human proto-oncogenes by AAV, the expression of three marker coding sequences ligated 3' of the proto-oncogene promoters were observed. Demonstrated here, the AAV Rep78 gene product was able to down-regulate the human c-fos and c-myc proto-oncogene promoters in all three assay systems. These interactions may partially explain AAVs anti-proliferation properties.

引用

页码：129 / 136

页数：8

共 37 条

[1]

BANTELSCHAAL U, 1992, J VIROL

[2] NOVEL PROMOTER UPSTREAM OF THE HUMAN C-MYC GENE AND REGULATION OF C-MYC EXPRESSION IN B-CELL LYMPHOMAS [J].

BENTLEY, DL ;

GROUDINE, M .

MOLECULAR AND CELLULAR BIOLOGY, 1986, 6 (10) :3481-3489

[3]

BLACKLOW NR, 1978, REPLICATION MAMMALIA, P87

[4]

CASTO BC, 1967, VIROLOGY, V18, P52

[5] HIGH-EFFICIENCY TRANSFORMATION OF MAMMALIAN-CELLS BY PLASMID DNA [J].

CHEN, C ;

OKAYAMA, H .

MOLECULAR AND CELLULAR BIOLOGY, 1987, 7 (08) :2745-2752

[6] EFFECT OF ADENO-ASSOCIATED VIRUS ON CANCER EXPRESSION BY HERPES-VIRUS-TRANSFORMED HAMSTER CELLS [J].

CUKOR, G ;

BLACKLOW, NR ;

KIBRICK, S ;

SWAN, IC .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1975, 55 (04) :957-959

[7] IDENTIFICATION OF A TRANSCRIPTIONAL ENHANCER ELEMENT UPSTREAM FROM THE PROTO-ONCOGENE FOS [J].

DESCHAMPS, J ;

MEIJLINK, F ;

VERMA, IM .

SCIENCE, 1985, 230 (4730) :1174-1177

[8] ANALYSIS OF PROTEINS, HELPER DEPENDENCE, AND SEROEPIDEMIOLOGY OF A NEW HUMAN PARVOVIRUS [J].

GEORGFRIES, B ;

BIEDERLACK, S ;

WOLF, J ;

HAUSEN, HZ .

VIROLOGY, 1984, 134 (01) :64-71

[9] RECOMBINANT GENOMES WHICH EXPRESS CHLORAMPHENICOL ACETYLTRANSFERASE IN MAMMALIAN-CELLS [J].

GORMAN, CM ;

MOFFAT, LF ;

HOWARD, BH .

MOLECULAR AND CELLULAR BIOLOGY, 1982, 2 (09) :1044-1051

[10] USE OF ADENO-ASSOCIATED VIRUS AS A MAMMALIAN DNA CLONING VECTOR - TRANSDUCTION OF NEOMYCIN RESISTANCE INTO MAMMALIAN TISSUE-CULTURE CELLS [J].

HERMONAT, PL ;

MUZYCZKA, N .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (20) :6466-6470

← 1 2 3 4 →