INFLAMMATORY FUNCTION OF MACROPHAGES FROM CHICKENS WITH B-RECOMBINANT HAPLOTYPES

被引：7

作者：

GOLEMBOSKI, KA

TAYLOR, RL

BRILES, WE

BRILES, RW

DIETERT, RR

机构：

[1] UNIV NEW HAMPSHIRE,DEPT ANIM & NUTR SCI,DURHAM,NH 03824

[2] NO ILLINOIS UNIV,DEPT BIOL SCI,DE KALB,IL 60115

来源：

AVIAN PATHOLOGY | 1995年 / 24卷 / 02期

关键词：

D O I：

10.1080/03079459508419074

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Both in vivo macrophage activation and in vitro monocyte activation were compared using chickens homozygous for each of two biochemically and serologically similar B-complex recombinant (B-F2-G23) haplotypes. Chickens carrying the parental (nonrecombinant) B haplotypes (B-2 and B-23) were included for relative comparison, although the genetic backgrounds for these strains were different from the background of the recombinants. Elicited peritoneal macrophages from R4/R4 (international designation B-2r3) chickens expressed levels of sheep erythrocyte phagocytosis which were significantly higher (P < 0.05) than those from R2/R2 (B-2r1) chickens. Differences between chickens with B genotypes were analogous to the differences demonstrated previously between B-2/B-2 and B-23/B-23 chickens. Similarly, lipopolysaccharide (LPS)-activated monocytes from R4/R4 chickens also expressed significantly higher (P < 0.05) levels of phagocytosis when compared with R2/R2 and B-23/B-23. In both cases, the functional level of macrophages from R2/R2 chickens was similar to that of B-23/B-23 cells, whereas macrophages from R4/R4 chickens were similar in functional capacity to those from B-2/B-2 chickens. These results suggest that R2 and R4 recombinants, despite their demonstrated similarities, may differ in DNA regions which include genetic factors controlling macrophage responsiveness.

引用

页码：347 / 352

页数：6

共 14 条

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